Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 2 de 2
Filtrar
Mais filtros










Base de dados
Intervalo de ano de publicação
1.
Cell Rep ; 29(9): 2546-2555.e4, 2019 11 26.
Artigo em Inglês | MEDLINE | ID: mdl-31775025

RESUMO

Antimicrobial peptides (AMPs) are the body's natural innate immune defense against a spectrum of pathogens and can also modulate cell proliferation, chemotaxis, angiogenesis, wound healing, and immune cell activity. Harnessing these diverse functions for prophylactic use is contingent upon understanding the regulatory mechanisms governing their unconventional secretion from cells. Analysis of the secretion of S100A7 (Psoriasin), an abundant AMP stored in differentiated keratinocytes of the skin, has revealed an unexpected biphasic secretory response to bacterial exposure. The core components regulating S100A7 secretion are NFκB/p38MAPK, caspase-1, and interleukin (IL)-1α. The initial activation of this core machinery is mediated by Toll-like receptor signaling, whereas the chronic response is mediated by Caspase-8 downregulation. Interestingly, there is a concomitant downregulation of Caspase-8 in inflammatory skin diseases wherein S100A7 is constitutively released. These results highlight the potential of targeting these components to control the release of AMPs from the skin in both homeostatic and disease conditions.


Assuntos
Anti-Infecciosos/uso terapêutico , Caspase 8/metabolismo , Proteína A7 Ligante de Cálcio S100/metabolismo , Anti-Infecciosos/farmacologia , Regulação para Baixo , Humanos
2.
Exp Dermatol ; 26(9): 827-829, 2017 09.
Artigo em Inglês | MEDLINE | ID: mdl-28094872

RESUMO

Antimicrobial peptides (AMPs) form a part of the skin's innate immune system. Their primary activity is to provide antimicrobial benefits and hence protect from infections. AMPs that are present on human skin include psoriasin (S100A7), RNase 7, lysozyme, LL-37 and defensins. Niacinamide is a well-known cosmetic ingredient that has been used traditionally for multiple skin benefits. Recent data indicate that niacinamide treatment can boost AMPs in human gut epithelial cells and in neutrophils. Treatment with niacinamide in mice also provided protection from skin infections by enhancing AMPs. In this article, we find that treatment with niacinamide formulation provides long-lasting protection against bacteria, potentially through the activation of an AMP response.


Assuntos
Escherichia coli/efeitos dos fármacos , Niacinamida/farmacologia , Pele/efeitos dos fármacos , Staphylococcus aureus/efeitos dos fármacos , Complexo Vitamínico B/farmacologia , Adulto , Voluntários Saudáveis , Humanos , Pele/microbiologia
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...