Cutaneous Intestinal Metaplasia With Adenocarcinoma Treated With Intralesional Fluorouracil.

This case report describes a patient with cutaneous intestinal metaplasia with invasive adenocarcinoma treated successfully with intralesional fluorouracil.

Impact of Vertical Inhomogeneity on the Charge Extraction in Perovskite Solar Cells: A Study by Depth-Dependent Photoluminescence.

In perovskite solar cells (PSCs), the vertical inhomogeneities which include uneven grains, voids, and grain boundaries are closely linked to the underlying charge transport layer which controls the nucleation and grain growth in the perovskite film. Herein, the vertical inhomogeneity of perovskite films in the device structure is analyzed by depth-dependent photoluminescence (PL) achieved with different excitation wavelengths. An analytical representation between vertical inhomogeneity and depth-dependent PL, parametrized with a factor, b, is introduced to understand the relation between inhomogeneity and charge recombination. Lower values of b correlate to lower vertical inhomogeneity and hence reduced recombination. The analytical representation is validated in two sets of devices that show remarkable differences in perovskite film morphology, device based on mesoporous TiO2 and planar SnO2. By exploring the morphological properties and the PL emission from different depths across the device structures, we show that the lower vertical inhomogeneity leads to more efficient charge carrier extraction in planar SnO2-based devices. Moreover, the SnO2-based devices exhibit lower Urbach energy, which concurs with the slow transient photovoltage decay, suggesting less defects and recombination losses. This work provides a broader understanding of the impact of vertical inhomogeneity on the charge extraction efficiency and presents a methodology to study quantitatively the inhomogeneity of perovskite films in device structures.

Hypothermic cardioplegia reduces the occurrence of spontaneous diastolic myofilament motion of the ischemic-reperfused rat heart.

Spontaneous diastolic myofilament motion of the isolated ischemic-reperfused rat heart was studied by the technique of laser spectroscopy. Scattered light intensity fluctuations (SLIF) from the exposed surface of the left ventricle of the quiescent perfused (Langendorff) rat heart were quantified by the autocorrelation function (R1F: frequency weighted by power), and by determining the average power of the SLIF signal (PS). The stabilized mean control (+/- SE) R1F (mV2/s2) and PS (mV2/s) values were: 0.87 +/- 0.07 and 21.3 +/- 1.5 respectively. SLIF were characterized to index the extent of cell Ca(2+)-loading and the integrity of the sarcoplasmic reticulum (SR) functions by low Na+ and ryanodine perfusions. Low Na+ perfusion significantly increased the R1F values and produced pronounced spectral peaks between 0.5 and 2.5 Hz frequency bands; whereas ryanodine (1 microM) perfusion completely abolished the SLIF signals. Ischemia (34 degrees C, 60 min.) produced nearly a 12-fold increase in the R1F and PS values accompanied by a four-fold increase in the left ventricular end-diastolic pressure (LVEDP) during the reperfusion period (34 degrees C, 30 min.) Pronounced reperfusion SLIF peaks were evident at the frequency bands between 0.25-5.0 Hz. Hypothermic (10 degrees C) preservation during ischemia reduced the frequency and the amplitude of the SLIF signals at various frequencies and prevented the rise in LVEDP. As compared to hypothermia alone, hypothermic cardioplegia offered a slightly better preservation. But hypothermia alone or in combination with cardioplegia failed to completely normalize the post-ischemic R1F and PS values.(ABSTRACT TRUNCATED AT 250 WORDS)