RESUMO
Studies in adult HT have demonstrated improved cardiac function in the recipient following administration of T3 to the donor. The purpose of this experiment was to assess the effects of T3 on the function of the immature donor heart following HT in a piglet model. A total of 32 piglets were divided into 16 donors and 16 recipients. Following creation of brain death, half of the donor piglets were randomized to receive three doses of T3 (0.2 µg/kg) along with hydrocortisone (1 mg/kg). The donor hearts were then transplanted into the recipient piglets on CPB. Duration of survival off CPB, inotrope score, and EF of heart following CPB were evaluated. There were no differences between the two groups in age, weight, pre-brain death EF, T3 levels, and CPB times. Post-CPB survival times were inversely related to the ischemic times in both groups (Pearson r=-0.80, P<.001), and this relationship was not influenced by T3. There was no difference in inotrope score, EF, or biochemical assessment between the two groups. Administration of T3 in combination with hydrocortisone to the brain-dead donor confers no beneficial effect on myocardial function or survival following HT in a piglet model.
Assuntos
Cardiotônicos/farmacologia , Transplante de Coração , Coração/efeitos dos fármacos , Coleta de Tecidos e Órgãos/métodos , Tri-Iodotironina/farmacologia , Animais , Morte Encefálica , Cardiotônicos/administração & dosagem , Esquema de Medicação , Feminino , Coração/fisiologia , Transplante de Coração/mortalidade , Humanos , Hidrocortisona/administração & dosagem , Hidrocortisona/farmacologia , Masculino , Distribuição Aleatória , Suínos , Doadores de Tecidos , Tri-Iodotironina/administração & dosagemRESUMO
We present a case of a rare tumor, a myxolipoma, appearing in a 5-year-old child, along with the imaging evaluation and surgical management. The natural history is expected to be that of a benign lesion, but the rarity precludes large studies.
Assuntos
Procedimentos Cirúrgicos Cardíacos , Neoplasias Cardíacas/diagnóstico , Neoplasias Cardíacas/cirurgia , Lipoma/diagnóstico , Lipoma/cirurgia , Mixoma/diagnóstico , Mixoma/cirurgia , Biópsia , Ponte Cardiopulmonar , Pré-Escolar , Humanos , Imageamento por Ressonância Magnética , Masculino , Valor Preditivo dos Testes , Resultado do TratamentoRESUMO
Vascular access in children who require extracorporeal membrane oxygenation (ECMO) support can be a challenging endeavor particularly in those who have undergone prior median sternotomies or interventional procedures. We present an alternative cannulation strategy that can be utilized in pediatric patients requiring ECMO that involves utilization of the iliac vein via a retroperitoneal approach.
Assuntos
Cateterismo/métodos , Oxigenação por Membrana Extracorpórea/métodos , Veia Ilíaca/cirurgia , Feminino , Humanos , Lactente , Espaço RetroperitonealRESUMO
Intrapericardial teratomas often present as life-threatening problems when diagnosed during fetal life. They are large lesions that compress the heart and lungs and can result in tamponade if not treated expeditiously. We present a case of a large teratoma that was managed by prenatal pericardiocentesis followed by surgical resection.