Platelet-Rich Plasma in the Management of Temporomandibular Joint Pain in Young Adults With Temporomandibular Disorder.

BACKGROUND: Temporomandibular disorder (TMD) encompasses a range of conditions affecting the temporomandibular joint (TMJ) and associated structures, with TMJ pain being a prevalent symptom. Conventional management strategies have limitations, which require the exploration of innovative interventions. Platelet-rich plasma (PRP), known for its regenerative properties, presents a potential therapeutic avenue. This study aims to investigate the effectiveness of PRP in reducing the pain associated with mild TMJ in young adults. METHODOLOGY: Participants (n = 128) aged 18 to 35 years with mild TMD were evenly randomized into PRP treatment and placebo control groups. PRP was prepared using a standardized protocol, and intra-articular injections were administered. Placebo injections mimic PRP. Follow-up evaluations were carried out at four and eight weeks after the intervention. RESULTS: The study successfully randomized comparable groups, and the PRP treatment group experienced a significant reduction in TMJ pain (visual analog scale [VAS] score: 6.8 ± 1.2 to 2.1 ± 1.0 at eight weeks, P < 0.001). The PRP treatment also increased the largest opening of the mouth (from 38.2 ± 2.5 to 43.5 ± 3.1, P < 0.001) and the number of lateral movements (12.3 ± 1.5 to 14.9 ± 2.0, P < 0.001), while the placebo group had very few changes. Positive patient-reported outcomes on daily activities were observed, with no serious complications reported in either group. CONCLUSIONS: This study provides evidence supporting the efficacy of PRP in reducing TMJ pain, improving jaw function, and improving quality of life in young adults with mild TMD. The results underscore the potential of PRP as a minimally invasive intervention for TMJ disorders.

Expression of CD105 in tumor angiogenesis a comparative study (ameloblastoma, keratocystic odontogenic tumor and dentigerous cyst).

BACKGROUND: Demonstrate the expression of CD105 (angiogenetic marker) in ameloblastoma (AM), keratocystic odontogenic tumor (KCOT) and dentigerous cyst (DC). MATERIAL AND METHODS: Assessment of microvessel density (MVD) in 70 cases, including 20 KCOT, 20 DC and 20 solid AMs. Assessment of MVD should be done as the mean number of microvessels per high-power-field. RESULTS: AM and KCOT demonstrated a higher mean value of 7.98 (±2.70) and 6.25 (±2.88) respectively while DC demonstrated a lower mean of 3.75 (±1.42). There was no statistically significant difference between AM and KCOT (P > 0.05). The difference between AM and DC; and between KCOT and DC were statistically significant (P < 0.05). CONCLUSION: The present study suggested that angiogenesis may be one of the mechanisms possibly contributing to the different biological behaviors of KCOT, DCs and solid AMs.