[Toxicity modifying action of remaxol by treatment of advanced oral cancer].

The efficiency of remaxol for prevention and treatment of chemoradiotherapy toxicity effects in patients with advanced oral cancer was evaluated. Ninety-five oral cancer patients were using remaxol both locally (mouth rinse solution) and by intravenous infusion, 87 patients were included in control group. Intravenous remaxol proved to be effective for mucositis and nephrotoxicity prevention by chemoradiotherapy.

[Supportive therapy for locally advanced cancer of the oral mucosa].

The article discusses the practice of detoxication therapy to minimize undesirable toxic effects during chemo- and radiotherapy for locally advanced cancer of the oral mucosa in 88 patients treated with 1.5% solution of reamberine. There was a significant improvement in the parameters of liver function, as well as in the general wellbeing of patients. We analyzed the main symptoms of the toxicity of chemo- and radiotherapy in both groups. Inclusion of the reamberine solution as supportive therapy for cancer patients who were receiving chemo- and radiotherapy for cancer of the oral mucosa allowed reducing the number and severity of toxic complications.

[Features of surgical intervention in patients with cancer of oral cavity organs after a radical course of radiotherapy]. / Osobennosti khirurgicheskikh vmeshatel'stv u bol'nykh rakom organov polosti rta posle radikal'nogo kursa luchevoi terapii.

The paper is concerned with the results of extended and combined operations on 58 patients, subjected to a previous radical course of beta-beam or combined (external and contact) irradiation for cancer of the oral cavity and oropharyngeal organs. Over 2 years after operation 50% of the patients are alive. Twenty-two patients died of tumor relapse, regional or distant metastases, one patient died of another tumor site, and 6 patients died from intercurrent diseases. The results obtained are indicative of the appropriateness of this kind of operations. The use of plastic surgery simultaneously with the removal of a primary tumor prevents severe postoperative complications.

[ICO-10 (Thy-1) and K-20 (gp 120/200) monoclonal antibodies in immunophenotyping of solid tumors in man]. / Monoklonal'nye antitela IKO-10 [Thy-1] i K-20 [gp 120/200] v immunofenotipirovanii solidnykh opukholei cheloveka.

ICO - 10 (Thy-1 antigen) and K 20 (gp 120/200) monoclonal antibodies proved suitable for immunophenotyping solid tumors. The following typical antigen combinations were identified with regard to reaction with those antibodies: ICO - 10+ K 20- (neuroblastoma, malignant schwannoma, neurosarcoma and soft tissue sarcomas); K 20+ ICO - 10- (cancer of the tongue and esophagus, adenoma of the adrenal cortex, adenocarcinoma of the stomach, hepatoblastoma and nephroblastoma); ICO - 10+ K 20+ (immature teratoma and cervical and esophageal leiomyoma) and ICO - 10+ K 20- (malignant fibrous histiocytoma).

[Hyperthermia in combined radiotherapy of cancer of the mouth mucosa]. / Gipertermiia pri sochetannoi luchevoi terapii raka slizistoi obolochki rta.

Combined treatment of patients with cancer of the oral mucosa using a dynamic course of irradiation in combination with local hyperthermia was proposed. Altogether 55 patients were treated, of them in 51 (92.7%) complete tumor regression was achieved. The short-term results were indicative of the efficacy of the above method.

[Short-term results of radiotherapy of cancer of the tongue and mouth floor mucosa using 60Co and 252Cf]. / Blizhaishie resul'taty luchevoi terapii raka slizistoi obolochki iazyka i dna polosti rta s primeneniem 60Co i 252Cf.

The authors presented the immediate and 3-year results of interstitial and combined therapy of 90 patients with cancer of the tongue and oral fundus mucosa. 60Co- and 252Cf-sources were employed in interstitial radiotherapy. There were no significant differences in therapeutic efficacy using different radiation sources. Some methodological aspects of administration of interstitial radiotherapy, radiation reactions and complications were covered.

[Primary dermoplasty with cervical pedicle flap after resection of locally spread mouth tumors]. / Pervichnaia kozhnaia plastika sheinym loskutom na nozhke pri udalenii mestno rasprostranennykh opukholei polosti rta

In the paper the authors report their experience with application of a jugular fatcutaneous pedicled graft for primary reconstruction of defects of the oral mucous membrane following resection of localy spread malignant tumors under conditions of preliminary radiotherapy. Results of the plasty in 30 patients are reported. The technic of cutting out the graft is described.