Predicting glomerular function from adjusted serum creatinine in renal transplant patients.

In 22 individuals with a renal graft the correlations between the renal clearance of polyfructosan (CLPF), renal creatinine clearance (CLcr)--established under the same conditions as CLPF--and the value of glomerular function predicted using the equation by Cocroft and Gault (PredCLcr) were followed up, at an interval of 2-3 months, for 8-22 months. A significant linear correlation (r = 0.777, p < 0.001) was found between PredCLcr and CLPF as well as between PredCLcr and CLcr (r = 0.801, p < 0.001). Equally significant correlations, however, were established when relating the serum concentrations of creatinine (Scr) to 1/CLPF (r = 0.784, p < 0.001) and Scr to 1/CLcr (r = 0.744, p < 0.001). The values of the PredCLcr/CLPF and PredCLcr/CLcr ratios during follow-up in one and the same individual may vary significantly. This fluctuation exceeds maximal error of the analytical methods employed in one third of the individuals examined. When considering stabilization or slow changes in graft function on the basis of PredCLcr and CLPF we found significant discrepancies in more than one half of the individuals examined (64%). The findings support the assumption that more accurate methods must be used to assess graft glomerular function on long-term follow-up.

[Relation between creatinine clearance and glomerular filtration in long-term monitoring of individuals with kidney transplants]. / Vztah mezi clearancí kreatininu a glomerulární filtrací pri dlouhodobém sledování jedincu s transplantovanou ledvinou.

The authors examined in 22 subjects with a transplanted kidney after 2- to 3-month intervals for a period of 8-22 months the renal creatinine clearance (Ccr) and glomerular filtration rate (GFR) based on polyfructosan clearance (CPF). The mean value of the Ccr was 72.9 (+/- 23.3) ml/min/1.73 m/ and CPF 52.0 (+/- 19.5) ml/min/1.73 m2. The mean value of the Ccr/CPF ratio was 1.45 (+/- 0.33) and the tubular creatinine secretion (Tcr) 4.8 (+/- 5.5) mumol/min/100 ml CPF. Between values of Ccr and CPF a significant correlation was found (r = 0.752, p < 0.001). The value of the Ccr/CPF ratio in the same individual varied markedly in the course of the follow up period. The differences between the maximal and minimal values of the ratio in the same subject were in 36% of the patients greater than could be explained by errors of the applied analytical methods. From comparison of values of creatinine clearance and polyfructosan clearance at the onset and at the end of the investigation period ensues than in one half of the investigated cases a discrepancy was found between changes of the investigated clearance values. The assembled findings are consistent with the ideal that tubular creatinine secretion in the transplanted kidney may vary considerably in the course of time. Due to significant changes of tubular creatinine secretion in the same subject discrepancies develop between changes of creatinine clearance and the GFR. When evaluating the long-term stabilization or small changes of GFR of the transplanted kidney only on the basis of creatinine clearance erroneous conclusions may be reached.

[Analysis of mammary gland tumors in dogs in the South Bohemian Region]. / Analýza nádoru mlécné zlázy psu v Jihoceském kraji.

149 biopsies and excisions of tumorous tissues of the mammary gland it bitches were examined histologically at a workplace of the State Veterinary Institute at Ceské Budejovice in the years 1970 to 1987. The tumours were classified according to the criteria recommended by the WHO classification system. The tumours were divided into three groups with respect to their histogenesis: epithelial (58.4%), mesenchymatous (2%) and mixed (39.6%). The ratio of malignant to benign tumours made 65.1% to 34.9%.

[Maduromycotic mycetoma in a horse]. / Maduromykotický mycetom kone.

A case of maduromycotic mycetoma (eumycetoma) in seven years old draught horse is described. The disease was localized in anal region and healed after surgical treatment. Attention is drawn to the necessity of distinguishing three types of mycosis in horses, characterized by the origin of tumor lesions - mycetomas, hyphomycosis and entomophthoromycosis - and information was gathered on their etiology and geographical occurrence. On the basis of the morphology of fungal elements traced in inflammated changed tissues and with regard to the existing findings on the origin of eumycetoma in animals, it was concluded that the disease described was probably caused by fungus Allescheria boydii Shear. Exact definition of the causative agent was impossible without mycological cultivation.