1.
Appl Radiat Isot
; 55(6): 789-91, 2001 Dec.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11761101
RESUMO
The reported synthetic pathway of 8-chloro-11-(4-methyl-1-piperazinyl)-11-[14C]-5H-dibenzo[b,e][1,4]diazapine (clozapine) was modified in several steps. The synthetic pathway was shortened by 60% and the total yield was increased from 6% to 23%.