RESUMO
Neomycin administered to rats subjected to lymphatic fistula and treated with 14C-labelled oleic acid did not decrease either the absorption or the esterification of this organic acid. The results appear to indicate that neomycin has no effect on the intestinal mucosa.
Assuntos
Antibacterianos/farmacologia , Absorção Intestinal/efeitos dos fármacos , Síndromes de Malabsorção/induzido quimicamente , Neomicina/farmacologia , Ácido Oleico/farmacocinética , Administração Oral , Anastomose Cirúrgica , Animais , Cateterismo , Esterificação/efeitos dos fármacos , Linfa/metabolismo , Síndromes de Malabsorção/fisiopatologia , Neomicina/toxicidade , Sistema Porta/metabolismo , Ratos , Esteatorreia/induzido quimicamente , Estômago , Ducto Torácico/cirurgiaRESUMO
Intragastrically administered 14C-triolein was observed in fistula-derived lymph from rats treated with neomycin and controls. Absorption was much reduced in the treated animals, indicating (contrary to the literature data) that neomycin malabsorption also occurs in this species. The slight amount absorbed followed normal routes. It is suggested that the antibiotic acts on the intestinal content and not on the mucosa.
Assuntos
Antibacterianos/farmacologia , Conteúdo Gastrointestinal/efeitos dos fármacos , Absorção Intestinal/efeitos dos fármacos , Síndromes de Malabsorção/induzido quimicamente , Neomicina/farmacologia , Trioleína/farmacocinética , Administração Oral , Anastomose Cirúrgica , Animais , Cateterismo , Esterificação/efeitos dos fármacos , Linfa/metabolismo , Síndromes de Malabsorção/fisiopatologia , Neomicina/toxicidade , Sistema Porta/metabolismo , Ratos , Esteatorreia/induzido quimicamente , Estômago , Ducto Torácico/cirurgiaAssuntos
Catecolaminas/urina , Ácidos Graxos não Esterificados/sangue , Nicotiana , Plantas Tóxicas , Fumar , Adulto , Humanos , MasculinoRESUMO
Urinary lacticodehydrogenase activity was determined in normal subjects and the results were compared with those observed in the more common renal diseases, in kidney and bladder tumours, and in arterial hypertension without nephropathic complications. A constant and well-defined increase was note in all serious diseases forms, particularly in tumours. Hypertension per se, however, was not accompanied by changes in normal enzyme excretion. Processing of the data indicated that this test might be of assistance in routine examinations for serious urinary diseases, especially cancer.
Assuntos
Glomerulonefrite/enzimologia , Hipertensão/enzimologia , Neoplasias Renais/enzimologia , L-Lactato Desidrogenase/metabolismo , Pielonefrite/enzimologia , Neoplasias da Bexiga Urinária/enzimologia , Adolescente , Adulto , Idoso , Glomerulonefrite/urina , Humanos , Hipertensão/urina , Neoplasias Renais/urina , Pessoa de Meia-Idade , Neoplasias da Bexiga Urinária/urinaRESUMO
Comparison is made between the results obtained with a new method for the determination of serum ASO titres based on rapid agglutination on slides with the use of polystyrene latex and those given by the classic haemolytic method. A virtually complete correspondence was observed between the two techniques and it is suggested that the new test be employed as a preliminary screening measure in the determination of serum ASO titres.