Severe Drug-Induced Liver Injury Due to Self-administration of the Veterinary Anthelmintic Medication, Fenbendazole.

Fenbendazole is an anthelmintic agent approved for veterinary applications. Even though it is not approved by the US Food and Drug Administration for human use, such use appears to be increasing due to the popularization of fenbendazole's potential anticancer effects by social media. We describe the first case of histologically confirmed severe drug-induced liver injury, hepatocellular pattern, associated with the self-administration of fenbendazole in a 67-year-old woman who presented with 2 weeks of jaundice. Liver function tests normalized in 3 months after the cessation of fenbendazole.

Landing wise program: feasibility study protocol for Parkinson's disease.

Regardless of the benefits of fall prevention programs, people with Parkinson's disease (PD) will still fall. Therefore, it is crucial to explore novel therapeutic approaches that are well-accepted and effective for addressing fall risk and the fear of falls among this population. The present study aims to assess the feasibility of the Landing Wise program as a therapeutic intervention for reducing the fear of falling in people with PD. A mixed-methods study will be conducted using convenience sampling to recruit 20 people with PD with a moderate concern of falling from a Parkinson's Patients Association. In addition to usual care, participants will attend 2 days per week, 90 min group sessions for 8 weeks. The intervention combines group cognitive behavioral intervention with the training of safe landing strategies. Feasibility will be assessed by six key domains (recruitment strategy and rates, enrollment, retention, acceptability, reasons for decline/withdrawal, and adverse events). Quantitative data will be analyzed using descriptive statistics to characterize the sample, followed by inferential statistics to evaluate differences in the Short Falls Efficacy Scale-International Scale, Movement Disorder Society Unified Parkinson's Disease Rating Scale, Timed Up Go, 6-Minutes Walking Distance, and fall frequency and severity scores between baseline and final assessment. Qualitative data will be analyzed using an inductive thematic analysis process. There is a growing interest in developing new effective therapeutic approaches for people with PD. If proven program feasibility, this study precedes a randomized controlled trial to establish the effectiveness of the Landing Wise program.

The Spectrum of Hepatic Critical Care During Pregnancy: A Clinical Review.

Hepatic disease during pregnancy can result in the development of critical illness requiring special attention from a multidisciplinary team with a low threshold for tertiary care transfer to provide access to liver transplantation. Management of this population requires taking into consideration the benefit and risks of both mother and fetus. A myriad of diseases has been recognized, some being unique to pregnancy while others are common to the general population. We present a review of the literature on the diagnosis, management, and prognosis of these diseases to aid in the optimization of care in this special population.

Sociodemographic Risk Factors for Depression in Patients With Chronic Liver Disease.

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Fatores epidemiológicos da infestação por Otodectes cynotis em cães no município de Cuiabá

Dentre os fatores causadores da otite externa destaca-se o ácaro Otodectes cynotis, parasito encontrado frequentemente noouvido de cães e gatos, com relevante importância na clínica médica de pequenos animais. Trezentos e vinte cães, residentesno município de Cuiabá, Mato Grosso, sendo 160 oriundos de um abrigo de cães e 160 de atendimentos clínicos no HospitalVeterinário da Universidade Federal de Mato Grosso tiveram seus condutos auditivos examinados, por otoscopia e peloexame do swab parasitológico, com o objetivo de se determinar a prevalência do parasitismo pelo ácaro O. cynotis. Osexames dos cães revelaram uma prevalência de 67,5% de animais portadores de otocariose na população do abrigo, contra21,5% dos cães atendidos no Hospital Veterinário, evidenciando uma diferença significativa (p 0,001) na prevalência entreas duas populações.