1.
Bioorg Med Chem Lett
; 21(8): 2406-9, 2011 Apr 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21414776
RESUMO
The total asymmetric synthesis of (+)- and (-)-clusianone and (+)- and (-)-clusianone methyl enol ether is reported. Asymmetric induction is achieved through the use of ACC alkylation, providing the key intermediates with an er of 99:1. The four synthetic compounds were evaluated for their anti-HIV activity. Both (+)- and (-)-clusianone displayed significant anti-HIV activity.