Pseudoaneurysm of abdominal aorta: a complication of intrahepatic arterial infusion therapy.

Arterial perforation by an indwelling intrahepatic catheter for infusion chemotherapy occurred in a 69-year-old man with liver metastases from rectal cancer. Computed tomography demonstrated a pseudoaneurysm formation and was diagnostic of the complication.

DNA cytophotometry on atypical glands in stomach carcinogenesis of dogs induced by N-methyl-N'-nitro-N-nitrosoguanidine.

Microspectrophotometric measurement of the DNA content of cell nuclei was performed on the lesions (including atypical glands) in gastric carcinogenesis of 15 male beagle dogs, which had been induced by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). The distribution patterns of DNA content were classified into three types: normal, subnormal, and abnormal. The histograms of the distribution in normal and regenerative glands were a normal type and subnormal type, respectively, while adenocarcinoma showed an abnormal distribution type. In atypical glands, the distribution patterns in autopsy cases were subnormal and abnormal types. When sequential endoscopic observation of the angulus of the stomach in dog No. 3 was carried out, atypical glands were found in an ulcer in the early stage of MNNG administration and a precancerous lesion in the late stage after termination of MNNG. The atypical glands in the early stage were of the subnormal type, while the atypical glands in the late stage were of the abnormal type. According to the results, these two types-subnormal and abnormal - of distribution of DNA content on the atypical glands may be related to regeneration and subsequent development of cancer, respectively.

Endoscopic study of chronological changes leading to cancer in the esophagus of dogs induced by N-ethyl-N'-nitro-N-nitrosoguanidine.

An endoscopical study of chronological change during the carcinogenetic process of cancer of the esophagus induced by N-ethyl-N'-nitro-N-nitrosoguanidine (ENNG) in 16 male beagle dogs was performed to clarity whether or not precancerous lesions exist in the esophagus. Redness was first observed in the mucosa in the lower and/or middle portions of the esophagus. A small nodule developed in the redness, followed by a nodule. The nodule then developed into a flat polyp which finally developed into lesions such as an elevated lesions, protrusions or elevations with depressions. Histologically, esophagitis or acanthosis in the redness and acanthosis were found in most of the small nodules. With regard to the nodules, papillomatosis was observed in half of the lesions, while either acanthosis or atypical epithelial proliferation were found in most of the flat polyps. Almost all the elevated or protruding lesions were found to be carcinoma.

Regression of polyploid carcinoma induced by N-methyl-N'-nitro-N-nitrosoguanidine in the stomach of a dog.

Polyploid carcinoma in the gastric antrum of a Beagle dog induced by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) was sequentially studied by endoscopy and biopsy. Ulcer appeared on the angulus of the stomach at the 28th week and resulted in ulcer scar at the 42nd week. A new depression with atypical glands arose on the ulcer scar at the 69th week, developed elevated border at the 77th week, and progressed to a polyploid lesion at the 90th week. Well-differentiated adenocarcinoma in situ was found in the polyploid lesion at the 97th week. It gradually grew with nodular change of its surface. However, the carcinoma was ulcerated at the 126th week, became an elevated lesion with central depression at the 138th week, and finally regressed at the 154th week. At necropsy on the 202nd week, no carcinoma was found in the stomach.