1.
Chemistry
; 25(43): 10226-10231, 2019 Aug 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31161639
RESUMO
A Pd-catalyzed enantiospecific and regioselective ring-opening Suzuki-Miyaura arylation of aziridine-2-carboxylates was developed. The cross-coupling allows for the asymmetric preparation of enantioenriched ß2 -aryl amino acids, starting from commercially available enantiopure d- and l-serine esters. The mechanism and selectivity of the reaction was rationalized based on computational models.