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1.
Acta Biomater ; 112: 213-224, 2020 08.
Artigo em Inglês | MEDLINE | ID: mdl-32413578

RESUMO

Biological materials tested in compression, tension, and impact inspire designs for strong and tough materials, but torsion is a relatively neglected loading mode. The wood skeletons of cholla cacti, subject to spartan desert conditions and hurricane force winds, provide a new template for torsionally resilient biological materials. Novel mesostructural characterization methods of laser-scanning and photogrammetry are used alongside traditional optical microscopy, scanning electron microscopy, and micro-computed tomography to identify mechanisms responsible for torsional resistance. These methods, in combination with finite element analysis reveal how cholla meso and macro-porosity and fibril orientation contribute to highly density-efficient mechanical behavior. Selective lignification and macroscopic tubercle pore geometry contribute to density-efficient shear stiffness, while mesoscopic wood fiber straightening, delamination, pore collapse, and fiber pullout provide extrinsic toughening mechanisms. These energy absorbing mechanisms are enabled by the hydrated material level properties. Together, these hierarchical behaviors allow the cholla to far exceed bamboo and trabecular bone in its ability to combine specific torsional stiffness, strength, and toughness. STATEMENT OF SIGNIFICANCE: The Cholla cactus experiences, due to the high velocity desert winds, high torsional loads. Our study has revealed the amazingly ingenious strategy by which the tubular structure containing arrays of voids intermeshed with wood fibers resists these high loads. Deformation is governed by compressive and tensile stresses which are greatest at 45 degrees to the cross section. It proceeds by stretching, sliding, and bending of the wood fibers which are coupled with the pore collapse, resulting in delayed failure and a high torsional toughness.


Assuntos
Opuntia , Análise de Elementos Finitos , Porosidade , Estresse Mecânico , Microtomografia por Raio-X
2.
Nano Lett ; 17(5): 2757-2764, 2017 05 10.
Artigo em Inglês | MEDLINE | ID: mdl-28384403

RESUMO

We report a new hybrid integration scheme that offers for the first time a nanowire-on-lead approach, which enables independent electrical addressability, is scalable, and has superior spatial resolution in vertical nanowire arrays. The fabrication of these nanowire arrays is demonstrated to be scalable down to submicrometer site-to-site spacing and can be combined with standard integrated circuit fabrication technologies. We utilize these arrays to perform electrophysiological recordings from mouse and rat primary neurons and human induced pluripotent stem cell (hiPSC)-derived neurons, which revealed high signal-to-noise ratios and sensitivity to subthreshold postsynaptic potentials (PSPs). We measured electrical activity from rodent neurons from 8 days in vitro (DIV) to 14 DIV and from hiPSC-derived neurons at 6 weeks in vitro post culture with signal amplitudes up to 99 mV. Overall, our platform paves the way for longitudinal electrophysiological experiments on synaptic activity in human iPSC based disease models of neuronal networks, critical for understanding the mechanisms of neurological diseases and for developing drugs to treat them.


Assuntos
Nanofios/química , Células-Tronco Neurais/metabolismo , Neurônios/metabolismo , Potenciais de Ação , Animais , Células Cultivadas , Humanos , Dispositivos Lab-On-A-Chip , Camundongos , Microeletrodos , Células-Tronco Neurais/citologia , Neurônios/citologia , Tamanho da Partícula , Ratos
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