1.
Mutat Res
; 328(2): 127-49, 1995 May.
Artigo
em Inglês
| MEDLINE
| ID: mdl-7739598
RESUMO
The results of short-term assays (induction of chromosomal aberrations and sister-chromatid exchanges, oncogenic transformations and cellular toxicity) together with MTD (maximum tolerated dose) values and physical chemical properties of non-genotoxic (i.e. Salmonella non-mutagens) carcinogens and non-carcinogens were submitted to RL, an inductive learning program. RL was able to learn rules that correctly predicted between 70 and 80% of non-genotoxic chemicals. This is a marked improvement over current predictions using only the results of short-term assays and exceeds the predictions of human experts that used the whole spectrum of acute and subchronic toxicity results as well as human knowledge and intuition.