1.
Bioorg Med Chem Lett
; 11(16): 2071-4, 2001 Aug 20.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11514141
RESUMO
A novel series of pyridopyrimidine analogues 9 was identified as potent adenosine kinase inhibitors based on the SAR and computational studies. Substitution of the C7 position of the pyridopyrimidino core with C2' substituted pyridino moiety increased the in vivo potency and enhanced oral bioavailability of these adenosine kinase inhibitors.