1.
Bioorg Med Chem Lett
; 13(3): 433-6, 2003 Feb 10.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12565945
RESUMO
A series of novel beta-amino acids has been synthesized and tested for their in vitro antifungal activity against Candida albicans. A steep SAR was observed. beta-Amino acid 21 (BAY 10-8888/PLD-118) revealed the most favourable activity-tolerability profile and was selected for clinical studies as a novel antifungal for the oral treatment of yeast infections.
