Gastrointestinal permeability during exercise: effects of aspirin and energy-containing beverages.

The purpose of this study was to determine whether aspirin (A) ingestion combined with prolonged exercise increases gastrointestinal permeability and whether consumption of a carbohydrate-containing (CHO) or a CHO + glutamine-containing (CHO+G) beverage would reduce this effect. Seventeen subjects completed six experiments. They ingested A (1,300 mg) or placebo (P) pills the evening before and before running 60 min at 70% maximal oxygen uptake. Also, before running they ingested a solution containing 5 g lactulose (L), 5 g sucrose (S), and 2 g rhamnose (R). During each trial, either a 6% CHO beverage, a 6% CHO+G (0.6%; 41 mM) beverage, or a water placebo (WP) was consumed. For 4 h after a run, all urine was collected to measure urinary excretion of L, R, and S. S excretion (percentage of dose ingested; measure of gastroduodenal permeability) was significantly greater (P < 0.05) during the A trial while the subjects drank the WP compared with all other trials. Administration of A also significantly increased L/R (measure of intestinal permeability) for the CHO and WP trials compared with all P trials. Ingestion the CHO or CHO+G beverages significantly reduced S excretion and L excretion when A was administered, but it did not reduce L/R. These results indicate that gastroduodenal and intestinal permeability increase after A ingestion during prolonged running and that ingestion of a CHO beverage attenuates the gastroduodenal effect but not the intestinal effect. Furthermore, addition of G to the CHO beverage provided no additional benefit in reducing gastroduodenal or intestinal permeability.

[The treatment of a case of postpartum uterine atony with consumption coagulopathy by therapeutic pharmaco angiography (author's transl)]. / Behandlung einer postpartalen Uterusatonie mit Verbrauchskoagulopathie durch therapeutische Pharmaco-Angiographie (Kasuistik).

Two hours following a twin stillbirth at 30 weeks gestation, a 25 year old primipara developed severe postpartum hemorrhage due to uterine atony and complicated by increasing consumption coagulopathy. Bilateral catheterization of the internal iliac arteries was attempted but only achieved on the left. For the next 22 hours the patient received 0.2 units per minute of Pitressin by intra-arterial infusion. The infusion was done more and more intermittently as the bleeding stopped and the coagulation parameters normalized. An emergency ligation of the internal iliac arteries or an emergency hysterectomy was thus avoided in this patient.