Beta-phosphorylated five membered ring nitroxides. Synthesis and EPR study.

A series of stable beta-phosphorylated five membered ring nitroxides was prepared by intramolecular aminomercuration of alkenyl alpha-aminophosphonates. The structure of these nitroxides was deduced from their 13C and 31P coupling constants and from force field calculations.

[Calcified lipogranuloma after gomenoleo oil injection: "paraffinoma" 60 years later]. / Lipogranulome calcifié après injection d'huile goménolée: un "paraffinome" 60 ans après.

The authors describe one case of calcified lipogranuloma observed in the forearm tissues of a 67 year old patient. This lesion seems to be due to a long term treatment by S.C injection of gomenoleo oil 60 years before. The analysis by high performance liquid chromatography of fat parts of the lesion identified the original olive oil (excipient).

[Acetylation phenotype of isoniazid in Morocco. Preliminary study of 100 cases]. / Phénotype d'acétylation de l'isoniazide au Maroc. Etude préliminaire sur 100 cas.

A preliminary study to determine the acetylator phenotype for Isoniazid was carried out for the first time on 100 patients. A correlation was shown between the blood and urinary methods; 59% were rapid acetylators and 41% slow acetylators, which were similar levels to those found in Black Africa. The predominance of rapid acetylators certainly explains the excellent tolerance of the high dose of INH (10 mg/kg) used in Morocco. If the determination of the acetylator phenotype could not be used systematically in our country, in view of the individual adaptation to the dosage--the dosage might, on the other hand be worked out in a prompt way before toxic signs appear at a dose of 10 mg/kg or under, of INH--thanks to the calculation of the index of inactivation estimated from a single sample.