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1.
J Nutr Biochem ; 114: 109272, 2023 04.
Artigo em Inglês | MEDLINE | ID: mdl-36681309

RESUMO

This study was designed to evaluate the long-term effects of Fructose (20%) feeding in rats, simulating metabolic syndrome (MetS), and the effects of coconut oil (C.O.) supplementation when administered in a MetS context. MetS is a cluster of systemic conditions that represent an increased chance of developing cardiovascular diseases and type 2 diabetes in the future. C.O. has been the target of media speculation, and recent studies report inconsistent results. C.O. improved glucose homeostasis and reduced fat accumulation in Fructose-fed rats while decreasing the levels of triglycerides (TGs) in the liver. C.O. supplementation also increased TGs levels and fructosamine in serum during MetS, possibly due to white adipose tissue breakdown and high fructose feeding. Pro-inflammatory cytokines IL-1ß and TNF-α were also increased in rats treated with Fructose and C.O. Oxidative stress marker nitrotyrosine is increased in fructose-fed animals, and C.O. treatment did not prevent this damage. No significant changes were observed in lipoperoxidation marker 4-Hydroxynonenal; however, fructose feeding increased total conjugated dienes and caused conjugated dienes to switch their conformation from cis-trans to trans-trans, which was not prevented by C.O. treatment. Potential benefits of C.O. have been reported with inconsistent results, and indeed we observed some benefits of C.O. supplementation in aiding weight loss, fat accumulation, and improving glucose homeostasis. Nonetheless, we also demonstrated that long-term C.O. supplementation could present some problematic effects with higher risk for individuals suffering MetS, including increased TGs and fructosamine levels and conformational changes in dienes.


Assuntos
Óleo de Coco , Suplementos Nutricionais , Síndrome Metabólica , Animais , Ratos , Glicemia/metabolismo , Óleo de Coco/farmacologia , Óleo de Coco/uso terapêutico , Diabetes Mellitus Tipo 2/etiologia , Diabetes Mellitus Tipo 2/metabolismo , Frutosamina/metabolismo , Frutosamina/farmacologia , Frutose/metabolismo , Glucose/metabolismo , Homeostase , Fígado/metabolismo , Síndrome Metabólica/dietoterapia , Síndrome Metabólica/metabolismo , Estresse Oxidativo , Ratos Wistar , Inflamação/dietoterapia , Inflamação/metabolismo
2.
Phytother Res ; 32(12): 2466-2474, 2018 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-30277282

RESUMO

Microbiota alterations are observed in pathological conditions, and their regulation is a subject of great interest. Gut microbes are affected by diet, and plant polyphenols may have positive effect on gut microbiota; however, plant-derived extracts may have toxic effects. Guarana (Paullinia cupana Mart.) is a nontraditional medicinal plant applied worldwide. Guarana yields an alkaloid and polyphenol-rich seed with antimicrobial, antioxidant, and anti-inflammatory properties, where caffeine is the major compound. We evaluated the effects of guarana seed powder (GSP) and purified caffeine on gut microbial composition and redox and inflammatory parameters in Wistar rats after 21 days of treatment. Fecal microbiota was analyzed utilizing 16S rDNA sequencing. Antioxidant enzymes activities from liver, kidney, and colon, as well as oxidative damage markers, were evaluated. Total nonenzymatic antioxidant potential was also evaluated. Microbiota was altered by both treatments, GSP and caffeine, without loss of diversity. In the liver, the kidney, and the colon, we observed a decrease in the antioxidant enzymes activities in the GSP group with no increase in the expression of oxidative damage markers, although some enzymes were also regulated by caffeine. Taken together, these results suggested that GSP ameliorates redox parameters but negatively affected gut microbiota, partially via caffeine.


Assuntos
Cafeína/farmacologia , Microbioma Gastrointestinal/efeitos dos fármacos , Estresse Oxidativo/efeitos dos fármacos , Teobromina/farmacologia , Teofilina/farmacologia , Animais , Antioxidantes/farmacologia , Cafeína/química , Disbiose/induzido quimicamente , Disbiose/microbiologia , Disbiose/patologia , Masculino , Oxirredução/efeitos dos fármacos , Paullinia/química , Extratos Vegetais/farmacologia , Plantas Medicinais/química , Ratos , Ratos Wistar , Sementes , Teobromina/química , Teofilina/química
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