RESUMO
BACKGROUND: During the past decade, ventricular assist devices as a bridge to transplantation have moved from the experimental arena to accepted therapy. Our institution has been at the forefront of the development of this technology and consequently has had extensive experience with the devices that are currently approved by the Food and Drug Administration for use as a bridge to heart transplantation. METHODS: The successful management of patients with assist devices hinges on patient and device selection as well as perioperative management strategies. The routine use of agents such as aprotinin, vasopressin, milrinone, and inhaled nitric oxide has contributed to successful management of these patients. We present our perspectives on the advantages and disadvantages of the Thermo-Cardiosystems HeartMate 1000 IP device and the Thoratec (Pierce-Donachy) system. We also discuss our protocols and methods for patient selection, preoperative preparation, intraoperative strategy, and postoperative management that have resulted in improved patient outcomes. RESULTS: More than 60 device implantation procedures have been performed since the inception of our bridge to transplantation program. During this time, two thirds of our patients were successfully bridged to transplantation. Of these patients, 92% were alive at 1 month after transplantation, and 83% were alive at 1 year after transplantation. CONCLUSIONS: Both support systems are effective in supporting patients to heart transplantation. We have developed a preference for the Thermo-Cardiosystems HeartMate 1000 IP device because of its portability and associated better quality of life. However, the Thoratec device is the more versatile device, and circumstances exist when its use is clearly advantageous. In our institutional experience, outcome for bridging to transplantation has not been device dependent.
Assuntos
Insuficiência Cardíaca/cirurgia , Transplante de Coração , Coração Auxiliar , Desenho de Equipamento , Seguimentos , Insuficiência Cardíaca/etiologia , Insuficiência Cardíaca/mortalidade , Mortalidade Hospitalar , Humanos , Seleção de Pacientes , Cuidados Pós-Operatórios , Análise de SobrevidaRESUMO
A technique to minimize injury to the bowel and its associated mesentery during difficult stoma creation is presented. A penrose drain is used to ensheathe the terminal segment of bowel, creating a uniform "tube" of intestine, protecting and facilitating delivery of the bowel through the abdominal wall.
Assuntos
Colostomia/métodos , Ileostomia/métodos , Músculos Abdominais/cirurgia , Drenagem/instrumentação , HumanosRESUMO
The excretion of total catecholamines in the urine of 18 females being in various stages of gestation was examined. These women did not take during their pregnancy any drug affecting the synthesis, storage, release, reuptake or metabolism of catecholamines. From the assessment of total catecholamines of 24 hours no statistically significant difference was observed as to the excretion of catecholamines as compared to the amount excreted by non-pregnant normal females.
