1.
Bioorg Med Chem Lett
; 14(1): 87-90, 2004 Jan 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-14684304
RESUMO
A series of (4-piperidinylphenyl)aminoethyl amides based on dipeptide anilines were synthesized and tested against cathepsin K, cathepsin L and cathepsin B. These new non-covalent inhibitors exhibited single-digit nM inhibition of the cysteine proteases. Compounds 3 and 7 demonstrated potency in both mouse and human osteoclast resorption assays.