RESUMO
BACKGROUND: Ziprasidone and bupropion are medications prescribed for mood and behavior disorders. They have apparently safe cardiac safety profiles in both therapeutic and supratherapeutic doses, but recently the Federal Drug Administration has issued a caution regarding ziprasidone use in combination with other drugs that are known to prolong the QTc interval. CASE REPORT: A 17-year-old male developed a widened QRS and a prolonged QTc interval following an overdose of ziprasidone and bupropion. He required hospital admission for aggressive cardiac monitoring and antidysrhythmic therapy, stabilizing to baseline by 80 hours postingestion. CONCLUSIONS: We present a case that underscores the potential cardiotoxicities of these medications. Ziprasidone and bupropion ingestion can be associated with cardiotoxicities that may require several days of aggressive cardiac monitoring and treatment.
Assuntos
Antidepressivos de Segunda Geração/intoxicação , Antipsicóticos/intoxicação , Bupropiona/intoxicação , Cardiopatias/induzido quimicamente , Piperazinas/intoxicação , Tiazóis/intoxicação , Adolescente , Antiarrítmicos/uso terapêutico , Estado de Consciência/efeitos dos fármacos , Transtorno Depressivo Maior/complicações , Transtorno Depressivo Maior/psicologia , Overdose de Drogas , Eletrocardiografia/efeitos dos fármacos , Cardiopatias/tratamento farmacológico , Humanos , Concentração de Íons de Hidrogênio , Lidocaína/uso terapêutico , Síndrome do QT Longo/induzido quimicamente , Síndrome do QT Longo/tratamento farmacológico , Masculino , Tentativa de SuicídioRESUMO
BACKGROUND: Ziprasidone (Geodon) and bupropion (Wellbutrin) are medications prescribed for mood and behavior disorders. They have apparently safe cardiac safety profiles in both therapeutic and supra-therapeutic doses. CASE REPORT: A 17-year-old male developed a widened QRS and a prolonged QTc interval following an overdose of ziprasidone and bupropion. He required hospital admission for aggressive cardiac monitoring and antidysrhythmic therapy, stabilizing to baseline by 80 hours post-ingestion. CONCLUSIONS: We present a case that underscores the potential cardiotoxicities of these medications. Ziprasidone and bupropion ingestion can be associated with cardiotoxicities that may require several days of aggressive cardiac monitoring and treatment.
