[Rapid production of a biotin deficiency in mice]. / Production rapide d'une carence en biotine chez la souris

This work describes a rapid method for the production of a biotin-deficiency in mice. Besides classical morphological symptoms, a decrease of activities of some biotin-dependent enzymes was also observed. The biotin-enzymes are not inhibited at the same extent in a same organ and the metabolic changes do not always follow the enzymatic modifications.