RESUMO
PURPOSE: to assess status of myocardial energy metabolism in patients with different etiology of left ventricular hypertrophy by phosphorus magnetic resonance spectroscopy (MRS) compared with healthy individuals. METHODS: The study included 94 people: 30 healthy volunteers (group 1), 35 patients with arterial hypertension and left ventricular hypertrophy (group II), 29 patients with hypertrophic cardiomyopathy (group III). All persons underwent cardiac magnetic resonance imaging (MRI) and MRS on high field MR scanner. Energy metabolism index (ratio of phosphocreatine and adenosine triphosphate concentrations [Pcr/ATP]) was used for evaluation of myocardial energy metabolism. RESULTS: Values of Pcr/ATP were 2.11 ± 0.29, 1.65 ± 0.12, and 1.32 ± 0.16 in groups I, II, and III, respectively (p < 0.05). CONCLUSION: 31P MRS is an effective tool of detection of disordered energy metabolism in hypertrophic myocardium. Combined use of MRI and MRS can become an effective method of comprehensive study of the heart.
Assuntos
Trifosfato de Adenosina/metabolismo , Metabolismo Energético , Hipertrofia Ventricular Esquerda/metabolismo , Espectroscopia de Ressonância Magnética/métodos , Miocárdio/metabolismo , Fosfocreatina/metabolismo , Feminino , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
Magnetic Resonant spectroscopy (MRS) in the nuclei of phosphorus is the only noninvasive method of studying the state of myocardial energy metabolism does not require the introduction of radiopharmaceuticals. This method uses the signals from the nuclei of 31P contained in such mattered phosphates like phosphocreatine and adenosine triphosphate. MRS can provide an answer to a variety of theoretical and clinical issues in the study of various cardiac diseases. The first is ischemic heart disease, as well as heart failure, hypertrophy of various origins, etc. In addition, the method can be used to control the various treatments, including therapeutic, interventional or surgical. Combined with magnetic resonance imaging of the heart gives information on the anatomy, size, function, perfusion defects, structural changes of the myocardium, as well as about the state of energy metabolism of myocardium.
Assuntos
Cardiopatias , Espectroscopia de Ressonância Magnética/métodos , Miocárdio/metabolismo , Trifosfato de Adenosina/metabolismo , Melhoramento Biomédico , Metabolismo Energético , Cardiopatias/diagnóstico , Cardiopatias/metabolismo , Humanos , Imageamento por Ressonância Magnética , Fosfocreatina/metabolismo , FósforoRESUMO
OBJECTIVE: To estimate the left ventricular (LV) energy index from the data of 31P-magnetic resonance spectroscopy (31P-MRS) in patients with hypertrophic cardiomyopathy (HCM) versus healthy individuals. SUBJECT AND METHODS: The investigation included 46 persons, including 30 healthy volunteers (Group 1) without cardiovascular diseases and 16 patients with HCM (Group 2). All the persons underwent cardiac magnetic resonance imaging (MRI) and 31P-MRS using a high-field Achieva 3T TX MRI scanner (Philips, Netherlands). ISIS location and adiabatic pulse with iterative shimming were used to collect data. RESULTS: The PC/ATP energy index (a phosphocreatine to adenosine triphosphate ratio) was employed to evaluate myocardial energy metabolism in the patients with HCM. The PC/ATP index was 2.08 +/- 0.35 in Group 1 and 1.32 +/- 3.3 in Group 2 (p < 0.05). CONCLUSION: 31P-MRS may be used to determine the myocardial energy metabolism in patients with HCM.
