[The immunomodulating action of interferon preparations. The effect of medicinal alpha-interferon preparations on the rosette-forming activity of human blood lymphocytes]. / K immunomoduliruiushchemu deistviiu preparatov interferona. Vliianie meditsinskikh preparatov al'fa-interferona na rozetkoobrazuiushchuiu aktivnost' limfotsitov krovi cheloveka.

Effects of alpha-interferon (alpha-IF) medical preparations on human blood lymphocyte rosette-forming activity was under study. Blood samples from 40 donors and 81 patients with chronic pyoderma, lupus erythematosus, and pemphigus were examined. Interferon preparations alpha-IF for nasal administration and IN-1 and IN-2 (or leukinterferon) for injections were used. The results evidence that IF preparations activities depend on the methods of the preparation synthesis and purification. alpha-IF and leukinterferon most effectively enhanced the lymphocyte ability to spontaneous, early, and active rosette formation. IN-1 was found less active and enhanced only the ability to spontaneous E-rosette formation, but had no effect on early active E-RFC subpopulations. IF preparations elevated the counts of E-RFC anf active RFC only if these levels were lowered; if these values were normal the agents had no effect.

[The clinical picture and laser photochemotherapy of obliterating xerotic balanoposthitis]. / Klinika i lazerofotokhimioterapiia kseroticheskogo obliteriruiushchego balanopostita.

Presents a detailed clinical description of two forms of xerotic obliterating balanoposthitis. Suggests a working classification of the condition, analyzes morphologic findings, proposes a new approach to therapy: laser photochemotherapy.

[The immune status indices of children with atopic dermatitis during sodium nucleinate therapy]. / Pokazateli immunnogo statusa detei, bol'nykh atopicheskim dermatitiom, v protsesse terapii nukleinatom natriia.

The immune status of 110 children, aged 6 months to 14 years, suffering from atopic dermatitis, was under study. The efficacy of sodium nucleinate included in combined therapy of these patients and its immunomodulating characteristics were examined in the children of various age groups. T- and B-cellular immunity components were found changed in all the patients, the most marked being shifts in the counts of B- and 0-lymphocytes, the ophyllin-resistant and autologous T-lymphocytes. Addition of sodium nucleinate to combined therapy improved the efficacy of treatment: the skin process activity was reduced, the periods of hospitalization shortened, and length of remissions prolonged.

[The clinico-immunological characteristics of patients with the typical and the erosive-ulcerative forms of lichen planus ruber]. / Kliniko-immunologicheskie osobennosti bol'nykh s tipichnoi i érozivno-iazvennoi formami krasnogo ploskogo lishaia.

Sixteen patients with typical and 17 with erosive ulcerative forms of lichen ruber planus were examined for the T- and B-immunity systems, myeloid series cells, complementary and spontaneous rosette-forming populations. B-lymphocyte levels were found elevated twofold in both groups of patients as against normal subjects. Patients with typical lichen planus developed a statistically significant elevation of T-lymphocyte count vs. normal subjects, whereas in patients with erosive ulcerative lichen planus this count was virtually unchanged. Reduced counts of active T-cells were detected in all the patients. The parameters of spontaneous and complementary rosette formation of neutrophils were different in the two groups of patients and in normal subjects. The counts of EAC-receptor carrying neutrophils were two times lower in the patients with erosive ulcerative lichen planus as against those with the typical form of the disease. Clinical manifestations correlated with changes in cell-mediated immunity factors; a marked defect of the neutrophilic receptor system has been detected, particularly manifest in erosive ulcerative lichen planus.

[The effect of therapy on the immunological indices in patients with skin lymphomas and Kaposi's sarcoma]. / Vliianie terapii na immunologicheskie pokazateli u bol'nykh limfomami kozhi i sarkomoi Kaposhi.

Manifest changes in the immunity status are detected in lymphoproliferative diseases of the skin and in Kaposi's sarcoma. Therapy results in elevation of the initially lowered levels of T mu- and T gamma-cells, this being a favorable result. Scintillation of T mu- and T gamma-cells may be used to monitor the efficacy of therapy in such patients.

[The pathogenesis of dermatoses due to contact with mineral fertilizers]. / O patogeneze dermatozov, obuslovlennykh kontaktom s mineral'nymi udobreniiami.

The studies have revealed unfavourable effect of mineral fertilizers on the peripheral blood cells. A complex of tests was used to diagnose dermatoses induced by exposure to mineral fertilizers.

[The immunomodulating action of interferon. The change in the rosette-forming activity of human blood lymphocytes under the influence of gamma-interferon and recombinant alpha 2-interferon]. / K immunomoduliruiushchemu deistviiu interferona. Izmenenie rozetkoobrazuiushchei aktivnosti limfotsitov krovi cheloveka pod vliianiem gamma-interferona i rekombinantnogo al'fa 2-interferona.

The authors analyze their findings in the study on the effects of interferon preparations (immune gamma-interferon and recombinant alpha 2-interferon) on the ability of blood lymphocytes of dermatoses patients and normal subjects to enter the rosette formation. Preliminary cell treatment with gamma-interferon in vitro essentially influences lymphocytic rosette forming activity, the initial functional activity of cellular receptor system being of paramount importance here. gamma-interferon increased cellular rosette-forming activity and virtually did not influence the unchanged parameters in the patients with lowered values by spontaneous and early active E-RFC. Besides that immune interferon increased the count of 'heavy' rosettes detectable in spontaneous and active E-rosette formation. Recombinant alpha 2-interferon did not essentially alter the blood lymphocyte receptor system.

[The immunomodulating action of interferon preparations. 3. Changes in the phagocytic activity of human blood neutrophilic granulocytes under the influence of interferon preparations]. / K immunomoduliruiushchemu deistviiu preparatov interferona. Soobshchenie 3. Izmenenie fagotsitarnoi aktivnosti neitrofil'nykh granulotsitov krovi cheloveka pod vliianiem preparatov interferona.

In vitro studies of phagocytosis-stimulating effects of interferon preparations differing in their origin and mode of purification were carried out with blood cells of dermatosis patients and healthy donors. Native preparations and preparations purified by sparing methods (alpha-interferon for intranasal administration and alpha-interferon for injections II) were found the most active: they induced a significant elevation of the activities of individual cells and of the count of actively phagocytizing cells. Phagocytosis-stimulating effect of well purified interferon preparations is essentially reduced. Recombinant alpha 2-interferon preparation has shown no such activity. A dose dependence of the effect of interferon preparations on blood neutrophil phagocytic activity has been revealed. The highest phagocytosis-stimulating effect of the above interferon preparations was observed in patients whose blood polymorphonuclear leukocyte phagocytic activity was essentially reduced.

[Expression of the class II antigens of the major histocompatibility complex on the blood cells of psoriasis patients and its alteration under the influence of interferon preparations]. / Ekspressiia antigenov glavnogo kompleksa gistosovmestimosti II klassa na kletkakh krovi bol'nykh psoriazom i ee izmenenie pod vliianiem preparatov interferonov.

The immune status, the level of expression of class II HLA histocompatibility antigens in the peripheral blood cells, and the effects on this antigen expression of alpha- and gamma-interferons have been examined in 21 patients with psoriatic arthropathy. Examinations of the immune status have revealed reduced levels of T-lymphocytes, of active E-RFC, of cells forming rosettes with autologous red cells, and an increased count of 0-lymphocytes. The level of class II antigen expression in monocytes, in total lymphocyte population, and in the fraction enriched for B-lymphocytes is much reduced in all the patients suffering from psoriatic arthropathy. The level of these antigens' expression in T-lymphocytes is increased in 2/3 of patients and unchanged in the rest. Intranasal alpha-interferon increased class II antigen expression in the peripheral blood monocytes of patients, whereas gamma-interferon induced no such effect. The stimulating effect of alpha-interferon on the patients' monocytes has been much less manifest than on normal donor monocytes. The antigen expression in the patients' blood lymphocytes exposed to alpha- and gamma-interferons has been virtually the same.

[Cellular immunity in patients with ulcerous forms of chronic pyoderma undergoing treatment]. / Kletochnyi immunitet u bol'nykh iazvennymi formami khronicheskoi piodermii v protsesse lecheniia.

Clinical and immunologic examinations of 55 patients suffering from ulcerous forms of chronic pyoderma have revealed increased counts of the peripheral blood theophylline-sensitive T-lymphocytes before therapy. A decrease of the level of this subpopulation, mainly responsible for the suppressor-cytotoxic function of T-cells, during combined therapy including prospidin is suggestive of an immunocorrecting effect of this drug.

[Dynamics of immunologic indices in patients with Kaposi's sarcoma during treatment with the preparation leakadine]. / Dinamika immunologicheskikh pokazatelei bol'nykh sarkomoi Kaposhi v protsesse lecheniia preparatom leakadinom.

Changes in the immunologic parameters of 39 patients with Kaposi's sarcoma over the course of leakadin therapy were under study, i. e. total leukocyte and lymphocyte counts, immunoregulatory cells in spontaneous and complementary rosette formation, and in that with monoclonal antibodies. The therapeutic efficacies and immunostimulating activities of prospidin and leakadin, a new Soviet drug, are compared. Besides sufficient therapeutic efficacy, leakadin has shown a manifest immunocorrective effect, increasing the counts of CD2+ and CD3+ cells, i. e. of the total T-lymphocyte pool (including the "young" cells) and, consequently, of its mature fraction, CD4+ and theophyllin-resistant T-lymphocytes, CD8+ cells; this fact recommends the drug for the treatment of patients with Kaposi's sarcoma. Since the immunomodulating effects of prospidin and leakadin are ambiguous, their combinations are advised for the treatment of Kaposi's sarcoma.