[Clinical evaluation of delayed and immediate hypersensitivity to antigens of the connective tissue, myocardium and hemolytic Streptococcus in patients with rheumatic fever]. / Klinicheskaia otsenka immunologicheskikh reaktsii zamedlennogo i nemedlennogo tipa k antigenam soedinitel'noi tkani, miokarda i gemoliticheskogo Streptokokka u bol'nykh revmatizmom

The results of a study of some humoral and cellular immunological reactions to antigens of the myocardium and connective tissues of cardiac vlaves, as well as to those of the haemolytic Streptococcus in rheumatic patients are presented. Antibodies to 4 antigens were deter mined, to cellular form of immunity was examined by the method of leucocytes migration inhibition. The studies have indicated that in rheumatism, hupersensitivity of a delayed and non-delayed type manifests itself. The activity of the inflammatory process, its severity, the nature and severity of carditis are to a great extent reflected by the connective tissue antibodies to the basic substance, especially to the structural glycoprotein of the valves. In cases of the most unfavourable clinical forms of the rheumatic process the signs of streptococcal sensitization and autoallergy to both musclular and connective tissue cardiac structures are especially vivid.