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3.
Cureus ; 14(11): e31406, 2022 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-36382323

RESUMO

Endofibrosis is a rare disease that predominantly affects athletes and is caused by a gradual occlusion of the (usually iliac) artery due to a thickening of the intima. From our experience, we report in this article two cases with the entity of endofibrosis in females around 30 years old. The first case presented with acute limb ischemia, and the second one was with pain in the leg during exercise. In addition, both cases are professional cyclists. They were eventually diagnosed with endofibrosis and underwent surgical procedures. They are now pursuing their professional career successfully. Last but not least, endofibrosis might be classified as an occupational disease, particularly, in the case of professional athletes or cyclists.

4.
J Clin Endocrinol Metab ; 107(3): 755-775, 2022 02 17.
Artigo em Inglês | MEDLINE | ID: mdl-34669916

RESUMO

CONTEXT: Adipose tissue distribution is a key factor influencing metabolic health and risk in obesity-associated comorbidities. OBJECTIVE: Here we aim to compare the proteomic profiles of mature adipocytes from different depots. METHODS: Abdominal subcutaneous (SA) and omental visceral adipocytes (VA) were isolated from paired adipose tissue biopsies obtained during bariatric surgery on 19 severely obese women (body mass index > 30 kg/m2) and analyzed using state-of-the-art mass spectrometry. Differential expression analysis and weighted gene co-expression network analysis (WGCNA) were performed to investigate proteome signature properties and to examine a possible association of the protein expression with the clinical data. RESULTS: We identified 3686 protein groups and found 1140 differentially expressed proteins (adj. P value < 0.05), of which 576 proteins were upregulated in SA and 564 in VA samples. We provide a global protein profile of abdominal SA and omental VA, present the most differentially expressed pathways and processes distinguishing SA from VA, and correlate them with clinical and body composition data. We show that SA are significantly more active in processes linked to vesicular transport and secretion, and to increased lipid metabolism activity. Conversely, the expression of proteins involved in the mitochondrial energy metabolism and translational or biosynthetic activity is higher in VA. CONCLUSION: Our analysis represents a valuable resource of protein expression profiles in abdominal SA and omental VA, highlighting key differences in their role in obesity.


Assuntos
Adipócitos/metabolismo , Gordura Intra-Abdominal/metabolismo , Obesidade Mórbida/metabolismo , Gordura Subcutânea Abdominal/metabolismo , Adulto , Cirurgia Bariátrica , Feminino , Redes Reguladoras de Genes , Humanos , Gordura Intra-Abdominal/citologia , Gordura Intra-Abdominal/patologia , Pessoa de Meia-Idade , Obesidade Mórbida/patologia , Obesidade Mórbida/cirurgia , Omento/citologia , Omento/metabolismo , Omento/patologia , Omento/cirurgia , Proteômica , Gordura Subcutânea Abdominal/citologia , Gordura Subcutânea Abdominal/patologia
5.
Wideochir Inne Tech Maloinwazyjne ; 9(2): 282-5, 2014 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-25097701

RESUMO

Although natural orifice specimen extraction is now relatively widely performed, there have been no reports on gastric resection with specimen extraction through the transgastric route for peptic ulcer disease. A hybrid technique of the laparoscopic and endoscopic approach is presented in the case of a 58-year old male patient. Preoperative gastric fibroscopy showed postulcer pyloric and antral stenosis. Laparoscopic exploration confirmed gastric enlargement. Laparoscopic two-thirds gastrectomy was performed. The staple line suture of the residual stomach was excised and the specimen was extracted through the esophagus and mouth with a gastroscope. Finally, the residual stomach was closed again using linear endostaplers. Reconstruction was performed according to the Roux-en-Y method. Gastric resection using natural orifice specimen extraction (NOSE) may be a feasible operative procedure. The NOSE with the combination of standard laparoscopy and specimen extraction through a natural orifice can be considered as a bridge to natural orifice translumenal endoscopic surgery.

6.
Indian J Surg ; 75(2): 94-101, 2013 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-24426401

RESUMO

The aim of our study was to evaluate the prognostic significance of blood transfusion on recurrence and survival in patients undergoing curative resections for colorectal cancer. Retrospective analysis of prospectively collected data of patients after elective resections for colorectal cancer between January 2001 and December 2009 was undertaken. The main endpoint was overall survival, disease-free survival, and recurrence rate. These data were evaluated in relation to blood transfusion (group A, no blood transfusion; group B, one to two blood transfusions; group C, three and more blood transfusions). A total of 583 patients met the criteria for inclusion in the study. Of these, 132 (22.6 %) patients received blood transfusion in the perioperative period. There were 83 (14.2 %) patients who received one or two blood transfusions and 49 (8.4 %) patients who required three or more transfusions. Patients with three or more transfusions had a significantly worse 5-year overall survival, disease-free survival, and increased incidence of distant recurrences in comparison with the group without transfusion or the group with one or two transfusions. Multivariate analysis showed that the application of three or more blood transfusions is an independent risk factor for overall survival (P = 0.001; HR 2.158; 95 % CI 1.370-3.398), disease-free survival (P < 0.001; HR 2.514; 95 % CI 1.648-3.836), and the incidence of distant recurrence (P < 0.001; HR 2.902; 95 % CI 1.616-5.212). Application of three or more blood transfusions in patients operated for colorectal carcinoma is an adverse prognostic factor. Indications for blood transfusion should be carefully considered not only with regard to the risk of early complications, but also because of the possibility of compromising long-term results.

7.
World J Gastroenterol ; 14(42): 6581-3, 2008 Nov 14.
Artigo em Inglês | MEDLINE | ID: mdl-19030218

RESUMO

Retrorectal cysts are rare benign lesions in the presacral space which are frequently diagnosed in middle-aged females. We report here our experience with two symptomatic female patients who were diagnosed as having a retrorectal cyst and managed using a laparoscopic approach. The two patients were misdiagnosed as having an ovarian cystic lesion after abdominal ultrasonography. Computer tomograghy (CT) scan was mandatory to establish the diagnosis. The trocar port site was the same in both patients. An additional left oophorectomy was done for a coexisting ovarian cystic lesion in one patient in the same setting. There was no postoperative morbidity or mortality and the two patients were discharged on the 5th and 6th post operative days, respectively. Our cases show that laparoscopic management of retrorectal cysts is a safe approach. It reduces surgical trauma and offers an excellent tool for perfect visualization of the deep structures in the presacral space.


Assuntos
Cistos/cirurgia , Laparoscopia , Doenças Retais/cirurgia , Adulto , Cistos/patologia , Feminino , Humanos , Cistos Ovarianos/complicações , Cistos Ovarianos/cirurgia , Ovariectomia , Doenças Retais/complicações , Doenças Retais/patologia , Tomografia Computadorizada por Raios X , Resultado do Tratamento
8.
Hepatogastroenterology ; 54(74): 393-6, 2007 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-17523282

RESUMO

In European countries, choledochal cysts are rare anomalies of the bile tract. At the Surgery Department of the University Hospital Ostrava, a case of a patient with cystic lesion of the pancreatic head was solved. According to ultrasonography and computer tomography it was assumed to be a pancreatic pseudocyst. Only after a complete additional examination of the pancreatico-biliary system, was it diagnosed Ia-type cystic dilatation of the common bile duct, accompanied by stenosis in its terminal part. With regard to the age of the first clinical symptoms, their character and histopathological findings, congenital origin is assumed in both of these anomalies. After provisional percutaneous transhepatic biliary drainage, a duodenohemipancreatectomy was performed with complete cyst excision. Until now, nine months later, the patient has shown absolutely no clinical difficulties.


Assuntos
Cisto do Colédoco/diagnóstico , Pseudocisto Pancreático/diagnóstico , Adulto , Colangiopancreatografia Retrógrada Endoscópica , Colangiopancreatografia por Ressonância Magnética , Cisto do Colédoco/cirurgia , Colestase Extra-Hepática/diagnóstico , Colestase Extra-Hepática/cirurgia , Colestase Intra-Hepática/diagnóstico , Colestase Intra-Hepática/cirurgia , Descompressão Cirúrgica , Diagnóstico Diferencial , Drenagem , Endoscopia , Humanos , Testes de Função Hepática , Masculino , Procedimentos Cirúrgicos Minimamente Invasivos , Pseudocisto Pancreático/cirurgia , Pancreaticoduodenectomia , Reoperação , Tomografia Computadorizada por Raios X , Ultrassonografia
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