[Hormonal status and overexpression of HER2 in breast cancer, Cancerology department of Treichville UHC. Preliminary results]. / Prévalence des récepteurs hormonaux et de HER2 dans le cancer du sein au service de cancérologie du CHU de Treichville. Résultats préliminaires.

MAIN OBJECTIVE: determine the profile of the hormonal receptors and HER2 in order to optimize the patient's treatment by hormonotherapy and to propose targeted therapeutic to the few patients can procure themselves, when the indication is put. SECONDARY OBJECTIVES: show the feasibility of these exams in sub-Saharan Africa and also the necessity to improve the technical tray permitting to do these exams in routine thus. PATIENTS AND METHODS: Preliminary results of a prospective, descriptive study, on 10 months, achieved to the Cancerology service of Treichville CHU in Abidjan (Ivory Coast). Our results were about 22 patients. RESULTS: The middle age of our patients was of 42.7 years. The stages to the diagnosis were advanced (86%) with nodes metastasis (77%), 8 patients out of 20 were RH+ of which only one postmenopausal patient, 8 patients out of 20 were HER2+ of which 2 to 2++ and 6 to 3+++. The FISH test has been achieved for the 2 positive patients to 2 ++ by IHC and came back positive. One of patients HER2+ could have adjuvant Herceptin. CONCLUSION: Breast cancer is bad prognosis affection in our developing countries because of the patient's young age, of the advanced stages to the diagnosis. The knowledge of the status of the hormonal receptors and the HER2 over expression is necessary, as well the importance to pursue this survey and to set up an immunohistochemy unit in Ivory Coast. It will permit the realization in routine of these exams and, then, the improvement of the breast cancer patient's treatment.

Interdisciplinarité oncologues réanimateurs dans l'administration des anticorps monoclonaux aux patients atteints de cancers : expérience abidjanaise

Les thérapeutiques ciblées ont entraîné un bouleversement dans la prise en charge et le pronostic de certains cancers. Parmi elles; les anticorps monoclonaux qui ont des effets indésirables non négligeables qui peuvent être grave mettant en jeu le pronostic vital. Les auteurs rapportent leur expérience de collaboration dans l'administration et la maitrise de ces traitements dans le Service de Cancérologie du CHU de Treichville à Abidjan

Cancer du sein chez la femme jeune : aspects anatomo-cliniques en milieu ivoirien

Pendant la periode 1992-1997; le cancer du sein a represente la premiere localisation des cancers dans le service de cancerologie du CHU d'Abidjan. Pas moins de 10 femmes de moins de 40 ans ont ete colligees. Le diagnostic est tardif dans 80;2 pour cent ; le type histologique le plus rencontre est le carcinome canalaire infiltrant 78 pour cent. L'envahissement ganglionnaire depassant souvent 3 ganglions 60;2 et le grade II/III 81 pour cent plaident en faveur d'un cancer de mauvais pronostic