Assuntos
Técnicas de Química Combinatória , Oligonucleotídeos/química , Ácidos Nucleicos Peptídicos/química , Sequência de Bases , Oligonucleotídeos/análise , Oligonucleotídeos/síntese química , Ácidos Nucleicos Peptídicos/análise , Ácidos Nucleicos Peptídicos/síntese química , Análise de Sequência de DNARESUMO
Mono- and alpha,omega-bis-styryl-oligo(oxyethylene glycol) ethers have been constructed in an efficient two-step synthesis. From these precursors, poly(oxyethylene glycol) polymer (POP) supports of varying monomer and cross-linker composition have been produced. The swelling properties and mass-solvent uptake of these novel materials have been evaluated in a variety of solvents, demonstrating that POP supports exhibit enhanced solvent compatibilities over the commercial resins TENTA-GEL, ARGO-GEL, and Merrifield's resin. The utility of POP supports in solid-phase organic chemistry has also been demonstrated successfully. It is anticipated that these high-loading polymeric supports will have generic application in the solid-phase synthesis of combinatorial libraries and the in situ screening of these libraries in the aqueous environment of a bioassay.
