Effect of a modulated acoustic field on the dynamics of a vibrating charged bubble.

We investigate the effect of amplitude-modulated acoustic irradiation on the dynamics of a charged bubble vibrating in a liquid. We show that the potential V(x) of the bubble, and the number and stability of its equilibria, depend on the magnitude of the charge it carries. Under high-frequency amplitude-modulation, a modulation threshold, Gth, was found for the onset of increased bubble amplitude oscillations. For some pressure field values, charge can facilitate the control of chaotic dynamics via reversed period-doubling bifurcation sequences. There is evidence for peak-shouldering and shock waves. The Mach number increases rapidly with the drive amplitude G. In the supersonic regime, for G>1.90Pa, the high-frequency modulation raises both Blake's and the transient cavitation thresholds. We found a decrease in the bubble's maximum charge threshold, and threshold modulation amplitude for the occurrence Vibrational resonance (VR). VR occurs due to the modulated oscillatory pressure field, and the influence on VR of the electrostatic charge, and other parameters of the system are investigated. In contrast to the cases of VR reported earlier, where the amplitude G of the high-frequency driving is typically much higher than the amplitude of the low-frequency driving (Ps), the VR resonance peaks occur here at relatively low G values (0

Nonlinear growth and mathematical modelling of COVID-19 in some African countries with the Atangana-Baleanu fractional derivative.

We analyse the time-series evolution of the cumulative number of confirmed cases of COVID-19, the novel coronavirus disease, for some African countries. We propose a mathematical model, incorporating non-pharmaceutical interventions to unravel the disease transmission dynamics. Analysis of the stability of the model's steady states was carried out, and the reproduction number R 0 , a vital key for flattening the time-evolution of COVID-19 cases, was obtained by means of the next generation matrix technique. By dividing the time evolution of the pandemic for the cumulative number of confirmed infected cases into different regimes or intervals, hereafter referred to as phases, numerical simulations were performed to fit the proposed model to the cumulative number of confirmed infections for different phases of COVID-19 during its first wave. The estimated R 0 declined from 2.452-9.179 during the first phase of the infection to 1.374-2.417 in the last phase. Using the Atangana-Baleanu fractional derivative, a fractional COVID-19 model is proposed and numerical simulations performed to establish the dependence of the disease dynamics on the order of the fractional derivatives. An elasticity and sensitivity analysis of R 0 was carried out to determine the most significant parameters for combating the disease outbreak. These were found to be the effective disease transmission rate, the disease diagnosis or case detection rate, the proportion of susceptible individuals taking precautions, and the disease infection rate. Our results show that if the disease infection rate is less than 0.082/day, then R 0 is always less than 1; and if at least 55.29% of the susceptible population take precautions such as regular hand washing with soap, use of sanitizers, and the wearing of face masks, then the reproduction number R 0 remains below unity irrespective of the disease infection rate. Keeping R 0 values below unity leads to a decrease in COVID-19 prevalence.

Physics of Selective Conduction and Point Mutation in Biological Ion Channels.

We introduce a statistical and linear response theory of selective conduction in biological ion channels with multiple binding sites and possible point mutation. We derive an effective grand-canonical ensemble and generalized Einstein relations for the selectivity filter, assuming strongly coordinated ionic motion, and allowing for ionic Coulomb blockade. The theory agrees well with data from the KcsA K^{+} channel and a mutant. We show that the Eisenman relations for thermodynamic selectivity follow from the condition for fast conduction and find that maximum conduction requires the binding sites to be nearly identical.

Vibrational and stochastic resonances in driven nonlinear systems: part 2.

Nonlinearity is ubiquitous in both natural and engineering systems. The resultant dynamics has emerged as a multidisciplinary field that has been very extensively investigated, due partly to the potential occurrence of nonlinear phenomena in all branches of sciences, engineering and medicine. Driving nonlinear systems with external excitations can yield a plethora of intriguing and important phenomena-one of the most prominent being that of resonance. In the presence of additional harmonic or stochastic excitation, two exotic forms of resonance can arise: vibrational resonance or stochastic resonance, respectively. Several promising state-of-the-art technologies that were not covered in part 2 of this theme issue are discussed here. They include inter alia the improvement of image quality, the design of machines and devices that exert vibrations on materials, the harvesting of energy from various forms of ambient vibration and control of aerodynamic instabilities. They form an important part of the theme issue as a whole, which is dedicated to an overview of vibrational and stochastic resonances in driven nonlinear systems. This article is part of the theme issue 'Vibrational and stochastic resonance in driven nonlinear systems (part 2)'.

Vibrational resonances in driven oscillators with position-dependent mass.

The vibrational resonance (VR) phenomenon has received a great deal of research attention over the two decades since its introduction. The wide range of theoretical and experimental results obtained has, however, been confined to VR in systems with constant mass. We now extend the VR formalism to encompass systems with position-dependent mass (PDM). We consider a generalized classical counterpart of the quantum mechanical nonlinear oscillator with PDM. By developing a theoretical framework for determining the response amplitude of PDM systems, we examine and analyse their VR phenomenona, obtain conditions for the occurrence of resonances, show that the role played by PDM can be both inductive and contributory, and suggest that PDM effects could usefully be explored to maximize the efficiency of devices being operated in VR modes. Our analysis suggests new directions for the investigation of VR in a general class of PDM systems. This article is part of the theme issue 'Vibrational and stochastic resonance in driven nonlinear systems (part 1)'.

Vibrational and stochastic resonances in driven nonlinear systems.

Nonlinear systems are abundant in nature. Their dynamics have been investigated very extensively, motivated partly by their multidisciplinary applicability, ranging from all branches of physical and mathematical sciences through engineering to the life sciences and medicine. When driven by external forces, nonlinear systems can exhibit a plethora of interesting and important properties-one of the most prominent being that of resonance. In the presence of a second, higher frequency, driving force, whether stochastic or deterministic/periodic, a resonance phenomenon arises that can generally be termed stochastic resonance or vibrational resonance. Operating a system in or out of resonance promises applications in several advanced technologies, such as the creation of novel materials at the nano, micro and macroscales including, but not limited to, materials having photonic band gaps, quantum control of atoms and molecules as well as miniature condensed matter systems. Motivated in part by these potential applications, this 2-part Theme Issue provides a concrete up-to-date overview of vibrational and stochastic resonances in driven nonlinear systems. It assembles state-of-the-art, original contributions on such induced resonances-addressing their analysis, occurrence and applications from either the theoretical, numerical or experimental perspectives, or through combinations of these. This article is part of the theme issue 'Vibrational and stochastic resonance in driven nonlinear systems (part 1)'.

Acoustic vibrational resonance in a Rayleigh-Plesset bubble oscillator.

The phenomenon of vibrational resonance (VR) has been investigated in a Rayleigh-Plesset oscillator for a gas bubble oscillating in an incompressible liquid while driven by a dual-frequency force consisting of high-frequency, amplitude-modulated, weak, acoustic waves. The complex equation of the Rayleigh-Plesset bubble oscillator model was expressed as the dynamics of a classical particle in a potential well of the Liénard type, thus allowing us to use both numerical and analytic approaches to investigate the occurrence of VR. We provide clear evidence that an acoustically-driven bubble oscillates in a time-dependent single or double-well potential whose properties are determined by the density of the liquid and its surface tension. We show both theoretically and numerically that, besides the VR effect facilitated by the variation of the parameters on which the high-frequency depends, amplitude modulation, the properties of the liquid in which the gas bubble oscillates contribute significantly to the occurrence of VR. In addition, we discuss the observation of multiple resonances and their origin for the double-well case, as well as their connection to the low frequency, weak, acoustic force field.

Quantum vibrational resonance in a dual-frequency-driven Tietz-Hua quantum well.

We investigate the response of a quantum particle in the Tietz-Hua quantum potential driven by biharmonic fields: a low-frequency force and a very high frequency force. The response is characterized by the occurrence of a maximum in the first-order transition probability amplitude |s|^{2} under the influence of the applied fields. It is shown that in the absence of the high-frequency component of the applied fields, |s|^{2} shows a distinct sequence of resonances, whereas an increase in the amplitude of the high-frequency field induces minima in |s|^{2}. However, the |s|^{2} maximum occurs in the low-frequency regime where it may be considered otherwise weak in the presence of a single harmonic force.

Ionic Coulomb blockade and the determinants of selectivity in the NaChBac bacterial sodium channel.

Mutation-induced transformations of conductivity and selectivity in NaChBac bacterial channels are studied experimentally and interpreted within the framework of ionic Coulomb blockade (ICB), while also taking account of resonant quantised dehydration (QD) and site protonation. Site-directed mutagenesis and whole-cell patch-clamp experiments are used to investigate how the fixed charge Qf at the selectivity filter (SF) affects both valence selectivity and same-charge selectivity. The new ICB/QD model predicts that increasing ∣Qf∣ should lead to a shift in selectivity sequences toward larger ion sizes, in agreement with the present experiments and with earlier work. Comparison of the model with experimental data leads to the introduction of an effective charge Qf∗ at the SF, which was found to differ between Aspartate and Glutamate charged rings, and also to depend on position within the SF. It is suggested that protonation of the residues within the restricted space of the SF is important in significantly reducing the effective charge of the EEEE ring. Values of Qf∗ derived from experiments on divalent blockade agree well with expectations based on the ICB/QD model and have led to the first demonstration of ICB oscillations in Ca2+ conduction as a function of the fixed charge. Preliminary studies of the dependence of Ca2+ conduction on pH are qualitatively consistent with the predictions of the model.

Calorimetric Observation of Single He 2 ∗ Excimers in a 100-mK He Bath.

We report the first calorimetric detection of individual He 2 ∗ excimers within a bath of superfluid 4 He . The detector used in this work is a single superconducting titanium transition edge sensor (TES) with an energy resolution of ∼ 1 eV , immersed directly in the helium bath. He 2 ∗ excimers are produced in the surrounding bath using an external gamma-ray source. These excimers exist either as short-lived singlet or long-lived triplet states. We demonstrate detection (and discrimination) of both states: In the singlet case the calorimeter records the absorption of a prompt ≈ 15 eV photon, and in the triplet case the calorimeter records a direct interaction of the molecule with the TES surface, which deposits a distinct fraction of the ≈ 15 eV , released upon decay, into the surface. We also briefly discuss the detector fabrication and characterization.

Vibrational resonance in an inhomogeneous medium with periodic dissipation.

The role of nonlinear dissipation in vibrational resonance (VR) is investigated in an inhomogeneous system characterized by a symmetric and spatially periodic potential and subjected to nonuniform state-dependent damping and a biharmonic driving force. The contributions of the parameters of the high-frequency signal to the system's effective dissipation are examined theoretically in comparison to linearly damped systems, for which the parameter of interest is the effective stiffness in the equation of slow vibration. We show that the VR effect can be enhanced by varying the nonlinear dissipation parameters and that it can be induced by a parameter that is shared by the damping inhomogeneity and the system potential. Furthermore, we have apparently identified the origin of the nonlinear-dissipation-enhanced response: We provide evidence of its connection to a Hopf bifurcation, accompanied by monotonic attractor enlargement in the VR regime.

Dissipation of Quasiclassical Turbulence in Superfluid

We compare the decay of turbulence in superfluid ^{4}He produced by a moving grid to the decay of turbulence created by either impulsive spin-down to rest or by intense ion injection. In all cases, the vortex line density L decays at late time t as L∝t^{-3/2}. At temperatures above 0.8 K, all methods result in the same rate of decay. Below 0.8 K, the spin-down turbulence maintains initial rotation and decays slower than grid turbulence and ion-jet turbulence. This may be due to a decoupling of the large-scale superfluid flow from the normal component at low temperatures, which changes its effective boundary condition from no-slip to slip.

The discriminatory value of cardiorespiratory interactions in distinguishing awake from anaesthetised states: a randomised observational study.

Depth of anaesthesia monitors usually analyse cerebral function with or without other physiological signals; non-invasive monitoring of the measured cardiorespiratory signals alone would offer a simple, practical alternative. We aimed to investigate whether such signals, analysed with novel, non-linear dynamic methods, would distinguish between the awake and anaesthetised states. We recorded ECG, respiration, skin temperature, pulse and skin conductivity before and during general anaesthesia in 27 subjects in good cardiovascular health, randomly allocated to receive propofol or sevoflurane. Mean values, variability and dynamic interactions were determined. Respiratory rate (p = 0.0002), skin conductivity (p = 0.03) and skin temperature (p = 0.00006) changed with sevoflurane, and skin temperature (p = 0.0005) with propofol. Pulse transit time increased by 17% with sevoflurane (p = 0.02) and 11% with propofol (p = 0.007). Sevoflurane reduced the wavelet energy of heart (p = 0.0004) and respiratory (p = 0.02) rate variability at all frequencies, whereas propofol decreased only the heart rate variability below 0.021 Hz (p < 0.05). The phase coherence was reduced by both agents at frequencies below 0.145 Hz (p < 0.05), whereas the cardiorespiratory synchronisation time was increased (p < 0.05). A classification analysis based on an optimal set of discriminatory parameters distinguished with 95% success between the awake and anaesthetised states. We suggest that these results can contribute to the design of new monitors of anaesthetic depth based on cardiovascular signals alone.

Regular rather than chaotic origin of the resonant transport in superlattices.

We address the enhancement of electron transport in semiconductor superlattices that occurs in combined electric and magnetic fields when cyclotron rotation becomes resonant with Bloch oscillations. We show that the phenomenon is regular in origin, contrary to the widespread belief that it arises through chaotic diffusion. The theory verified by simulations provides an accurate description of earlier numerical results and suggests new ways of controlling resonant transport.

Maximum amplitude of limit cycles in Liénard systems.

We establish sufficient criteria for the existence of a limit cycle in the Liénard system x[over ̇]=y-ɛF(x),y[over ̇]=-x, where F(x) is odd. In their simplest form the criteria lead to the result that, for all finite nonzero ɛ, the amplitude of the limit cycle is less than ρ and 0≤a≤ρ≤u, where F(a)=0 and ∫(0)(u)F(x)dx=0. We take the van der Pol oscillator as a specific example and establish that for all finite, nonzero ɛ, the amplitude of its limit cycle is less than 2.0672, a value whose precision is limited by the capacity of our symbolic computation software package. We show how the criterion for the upper bound can be extended to establish a bound on the amplitude of a limit cycle in systems where F(x) contains both odd and even components. We also show how the criteria can be used to establish bounds for bifurcation sets.

Glassy states and super-relaxation in populations of coupled phase oscillators.

Large networks of coupled oscillators appear in many branches of science, so that the kinds of phenomena they exhibit are not only of intrinsic interest but also of very wide importance. In 1975, Kuramoto proposed an analytically tractable model to describe these systems, which has since been successfully applied in many contexts and remains a subject of intensive research. Some related problems, however, remain unclarified for decades, such as the existence and properties of the oscillator glass state. Here we present a detailed analysis of a very general form of the Kuramoto model. In particular, we find the conditions when it can exhibit glassy behaviour, which represents a kind of synchronous disorder in the present case. Furthermore, we discover a new and intriguing phenomenon that we refer to as super-relaxation where the oscillators feel no interaction at all while relaxing to incoherence. Our findings offer the possibility of creating glassy states and observing super-relaxation in real systems.

Energetics of discrete selectivity bands and mutation-induced transitions in the calcium-sodium ion channels family.

We use Brownian dynamics (BD) simulations to study the ionic conduction and valence selectivity of a generic electrostatic model of a biological ion channel as functions of the fixed charge Q(f) at its selectivity filter. We are thus able to reconcile the discrete calcium conduction bands recently revealed in our BD simulations, M0 (Q(f)=1e), M1 (3e), M2 (5e), with a set of sodium conduction bands L0 (0.5e), L1 (1.5e), thereby obtaining a completed pattern of conduction and selectivity bands vs Q(f) for the sodium-calcium channels family. An increase of Q(f) leads to an increase of calcium selectivity: L0 (sodium-selective, nonblocking channel) → M0 (nonselective channel) → L1 (sodium-selective channel with divalent block) → M1 (calcium-selective channel exhibiting the anomalous mole fraction effect). We create a consistent identification scheme where the L0 band is putatively identified with the eukaryotic sodium channel The scheme created is able to account for the experimentally observed mutation-induced transformations between nonselective channels, sodium-selective channels, and calcium-selective channels, which we interpret as transitions between different rows of the identification table. By considering the potential energy changes during permeation, we show explicitly that the multi-ion conduction bands of calcium and sodium channels arise as the result of resonant barrierless conduction. The pattern of periodic conduction bands is explained on the basis of sequential neutralization taking account of self-energy, as Q(f)(z,i)=ze(1/2+i), where i is the order of the band and z is the valence of the ion. Our results confirm the crucial influence of electrostatic interactions on conduction and on the Ca(2+)/Na(+) valence selectivity of calcium and sodium ion channels. The model and results could be also applicable to biomimetic nanopores with charged walls.

Evolution of cardiorespiratory interactions with age.

We describe an analysis of cardiac and respiratory time series recorded from 189 subjects of both genders aged 16-90. By application of the synchrosqueezed wavelet transform, we extract the respiratory and cardiac frequencies and phases with better time resolution than is possible with the marked events procedure. By treating the heart and respiration as coupled oscillators, we then apply a method based on Bayesian inference to find the underlying coupling parameters and their time dependence, deriving from them measures such as synchronization, coupling directionality and the relative contributions of different mechanisms. We report a detailed analysis of the reconstructed cardiorespiratory coupling function, its time evolution and age dependence. We show that the direct and indirect respiratory modulations of the heart rate both decrease with age, and that the cardiorespiratory coupling becomes less stable and more time-variable.

Excimers He2* as tracers of quantum turbulence in 4He in the t = 0 limit.

We have studied the interaction of metastable 4He2* excimer molecules with quantized vortices in superfluid 4He in the zero temperature limit. The vortices were generated by either rotation or ion injection. The trapping diameter of the molecules on quantized vortices was found to be 96±6 nm at a pressure of 0.1 bar and 27±5 nm at 5.0 bar. We have also demonstrated that a moving tangle of vortices can carry the molecules through the superfluid helium.