1.
Bioorg Med Chem Lett
; 16(1): 88-92, 2006 Jan 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-16236496
RESUMO
The de novo molecular design program SPROUT has been applied to the X-ray crystal structures of Plasmodium and human dihydroorotate dehydrogenase, respectively. The resulting design templates were used to prepare a series of molecules which, in keeping with predictions, showed useful levels of species-selective enzyme inhibition.