RESUMO
This article evaluated the ability of propranolol to enhance results achieved with relaxation-biofeedback training. Thirty-three patients were randomized to relaxation-biofeedback training alone (administered in a limited-contact treatment format), or to relaxation-biofeedback training accompanied by long-acting propranolol (with dosage individualized at 60, 120, or 180 mg/day). Concomitant propranolol therapy significantly enhanced the effectiveness of relaxation-biofeedback training when either daily headache recordings (79% vs. 54% reduction in migraine activity) or neurologist clinical evaluations (90% vs. 66% reduction) were used to assess treatment outcome. Concomitant propranolol therapy also yielded larger reductions in analgesic medication use and greater improvements of quality of life measures than relaxation-biofeedback training alone but was more frequently associated with side effects.
Assuntos
Biorretroalimentação Psicológica/efeitos dos fármacos , Transtornos de Enxaqueca/terapia , Propranolol/administração & dosagem , Terapia de Relaxamento , Temperatura Cutânea/efeitos dos fármacos , Adolescente , Adulto , Terapia Combinada , Relação Dose-Resposta a Droga , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Transtornos de Enxaqueca/psicologia , Resultado do TratamentoRESUMO
7 women recorded number of miles walked per day and oral temperature daily upon rising for 6 weeks. Analysis of variance indicated no significant differences in activity level associated with cycle phases but individual differences in activity level among subjects were significant.