RESUMO
Four patients with chronic open-angle glaucoma developed a dendriform corneal epithelial lesion. Two were associated with the use of topical betaxolol for 2 months and 6 weeks, and two were related to topical levobunolol. Resolution occurred within 2 weeks of discontinuation of the beta-blocker eyedrop. The distinctive pattern of dendritic epithelial keratopathy associated with these topical medications may be due to epithelial toxicity with subsequent regeneration.
Assuntos
Antagonistas Adrenérgicos alfa/efeitos adversos , Doenças da Córnea/induzido quimicamente , Ceratite Dendrítica/induzido quimicamente , Antagonistas Adrenérgicos alfa/uso terapêutico , Idoso , Idoso de 80 Anos ou mais , Betaxolol/efeitos adversos , Betaxolol/uso terapêutico , Doença Crônica , Doenças da Córnea/patologia , Feminino , Glaucoma de Ângulo Aberto/tratamento farmacológico , Humanos , Levobunolol/efeitos adversos , Levobunolol/uso terapêutico , Masculino , Pessoa de Meia-IdadeRESUMO
We performed resections and recessions of scleral flaps on human cadaver eyes in order to measure the induced change in keratometric astigmatism. We prepared 3-mm scleral flaps that were 3, 5, 7, or 10 mm long and resected or recessed these flaps up to 1 mm in 0.25-mm increments. Scleral flap resection resulted in up to 10.1 D of net corneal steepening along the meridian of the incision. Scleral flap recessions resulted in up to 7.7 D of net corneal flattening along the meridian of the incision; the effect increased with increasing flap length in the recessed eyes. There was a tendency toward mean corneal flattening with resections and mean corneal steepening with recessions.