A systematic review investigating interventions that can help reduce consumption of sugar-sweetened beverages in children leading to changes in body fatness.

BACKGROUND: Both the prevalence of childhood obesity and the consumption of sugar-sweetened beverages (SSBs) have increased globally. The present review describes interventions that reduce the consumption of SSBs in children and determines whether this leads to subsequent changes in body fatness. METHODS: Three databases were searched from 2000 to August 2013. Only intervention control trials, ≥6 months in duration, which aimed to reduce the consumption of SSBs in >100 children aged 2-18 years, and reporting changes in body fatness, were included. The quality of selected papers was assessed. RESULTS: Eight studies met inclusion criteria. Six interventions achieved significant (P < 0.05) reductions in SSB intake, although this was not always sustained. In the two interventions providing replacement drinks, significant differences in body mass index (12- or 18-month follow-up) were reported (P = 0.001 and 0.045). The risk of being overweight/obesity was reduced (P < 0.05) in three of the five education programmes but in one programme only for girls who were overweight at baseline and in one programme only for pupils perceived to be at greater risk at baseline. In the one study that included both provision of water and education, the risk of being overweight was reduced by 31% (P = 0.04) in the intervention group. CONCLUSIONS: The evidence suggests that school-based education programmes focusing on reducing SSB consumption, but including follow-up modules, offer opportunities for implementing effective, sustainable interventions. Peer support and changing the school environment (e.g. providing water or replacement drinks) to support educational programmes could improve their effectiveness. Home delivery of more suitable drinks has a big impact on reducing SSB consumption, with associated reductions in body weight.

Whole School Mapping to Investigate the School Environment's Potential to Promote a Healthy Diet and Physical Activity in Malaysia

Introduction: The school is a vital part in the development of children's dietary practices as children consume a substantial proportion of their daily intake at school. The school environment offers an ideal location for health education and intervention against physical inactivity and poor nutritional intake. Methods: A mapping tool was developed to map the school environment on four levels: physical, economic, political, and socio-cultural that can potentially affect healthy eating and physical activity. The mapping was piloted and completed by interviewing twelve teachers (responsible for student affairs and the school curriculum), followed by observation at twelve randomly selected schools (six urban, six rural) in Terengganu, Eastern Peninsular Malaysia. Results: For physical environment, 55.0% of the criteria were met and while all schools taught nutrition and physical activity, this was not backed up with actual facilities for practising physical activity or food preparation. For economic environment, 17.7% of the criteria were met and eleven out of twelve schools had mobile caterers outside their front gates selling energy-dense food/drink. For political environment, 52.1% of the criteria were met and all teachers were aware of the existence of the national catering and nutrition guidelines, but they reported a lack of resources for implementation and monitoring. For socio-cultural environment, 59.2% of the criteria were met and all schools used sweet foods and drinks as rewards at large events. Conclusion: The findings suggest potential avenues exist for intervention in schools to provide a supportive environment that promotes healthier eating and physical activity to prevent obesity.

Reproducibility and relative validity of a brief quantitative food frequency questionnaire for assessing fruit and vegetable intakes in North-African women.

BACKGROUND: In the context of a rapidly increasing prevalence of noncommunicable diseases, fruit and vegetables could play a key preventive role. To date, there is no rapid assessment tool available for measuring the fruit and vegetable intakes of North-African women. The present study aimed to investigate the reproducibility and relative validity of an eight-item quantitative food frequency questionnaire that measures the fruit and vegetable intakes (FV-FFQ) of Moroccan women. METHODS: During a 1-week period, 100 women, living in the city of Rabat, Morocco (aged 20-49 years) completed the short FV-FFQ twice: once at baseline (FV-FFQ1) and once at the end of the study (FV-FFQ2). In the mean time, participants completed three 24-h dietary recalls. All questionnaires were administered by interviewers. Reproducibility was assessed by computing Spearman's correlation coefficients, intraclass correlation (ICC) coefficients and kappa statistics. Relative validity was assessed by computing Wilcoxon signed-rank tests and Spearman's correlation coefficients, as well as by performing Bland-Altman plots. RESULTS: In terms of reproducibility, Spearman's correlation coefficient was 0.56; ICC coefficient was 0.68; and weighted kappa was 0.35. In terms of relative validity, compared with the three 24-h recalls, the FV-FFQ slightly underestimated mean fruit and vegetable intakes (-10.9%; P = 0.006); Spearman's correlation coefficient was 0.69; at the individual level, intakes measured by the FV-FFQ were between 0.39 and 2.19 times those measured by the 24-h recalls. CONCLUSIONS: The brief eight-item FV-FFQ is a reliable and relatively valid tool for measuring mean fruit and vegetable intakes at the population level, although this is not the case at the individual level.

Innate immunity, gut integrity, and vitamin A in Gambian and Indian infants.

Gut integrity, which can be measured by the urinary lactulose:mannitol excretion test, deteriorates with the introduction of weaning foods. In The Gambia, gut integrity measured monthly over 15 months in 119 infants (aged 2-15 months) was least impaired from April to June. This coincides with the time of year of maximum vitamin A (VA) intake-the mango season. Subsequently, two VA intervention studies were done in infants in India. Eighty infants attending a community health center received 16,700 IU weekly or placebo. In another study, 94 hospitalized infants were given 200, 000 IU VA or placebo: 31 received VA on admission, while the rest (32 VA, 31 placebo) received treatment on discharge. All VA-treated groups had more rapid improvement in gut integrity than the placebo groups, but no group had gut integrity normalized by Western standards. The data suggest that VA status may influence gut integrity.

The effect of vitamin A on epithelial integrity.

Vitamin A is the generic term for a variety of fat-soluble substances including retinol, retinyl palmitate and the provitamin A carotenoids such as all-trans-beta-carotene. Vitamin A is commonly known as the anti-infective vitamin and has an essential role in vision and cellular differentiation, the latter providing a unique core mechanism helping to explain the influence of vitamin A on epithelial barriers. Alterations in the epithelial lining of vital organs occur early in deficiency, suggesting a potentially important role for the barrier function. Vitamin A deficiency (VAD) is most commonly recognized in the eye. The conjunctival-impression cytology test detects the presence of larger irregular keratinized cells and the absence of mucous-secreting goblet cells, indicative of VAD. The method is simple, quick and sensitive in populations where VAD is present. In the respiratory tract, observational studies all show an association with VAD, although vitamin A supplementation studies appear to have little effect on respiratory disease. Organ-specific targeting may improve success rates. The dual-sugar intestinal-permeability test allows the effect of vitamin A supplementation to be monitored on the gastrointestinal tract. Two vitamin A supplementation studies were carried out recently in Orissa State, India. Healthy infants of weaning age were administered orally eight weekly doses of 5.0 mg retinol equivalents and hospitalized infants received one large oral dose 60 mg retinol equivalents in the form of retinyl palmitate. Improvements in gut integrity and haematological status were observed in both studies. In summary, the response of the eye to vitamin A supplementation is well established; the present review highlights some of the more recent observations examining the effects of vitamin A.

S rod fixation to the sacrum in patients with neuromuscular spinal deformities.

A new form of pelvic fixation has been designed for use in patients with neuromuscular spinal deformities to overcome the problems imposed by the Galveston technique. One end of a Luque rod is prebent into an S shaped configuration and placed over the sacral ala supplying firm fixation across the lumbosacral junction without crossing the sacroiliac joint. It fixes firmly against the sacral ala by distracting against a hook or screw in the lumbar spine. A 12 year retrospective review of 67 patients with severe neuromuscular spinal deformities was accomplished. All surgeries were performed by one surgeon. All patients had good deformity correction with an average followup of 6 years and 2 months. Complications included: recurrence of pelvic obliquity (one patient), skin break-down over hardware (one patient), migration of hardware at sacrum (two patients), and rod breakage (five patients). The S rod is recommended for all patients with neuromuscular spinal deformities who require instrument fixation to the pelvis. Its ease of insertion and decreased operative time allow for a safe and dependable alternative fixation to the sacrum without crossing the sacroiliac joint.

Metrifonate in the control of urinary schistosomiasis in Zanzibar.

Selective population chemotherapy using three doses of metrifonate (7.5 mg/kg body weight each time) at two-week intervals was assessed in an entire community in Kinyasini district in Zanzibar, United Republic of Tanzania. The objectives of the study were to (1) reduce the prevalence of heavy infections (defined as greater than or equal to 50 S. haematobium eggs per 10 ml of urine) by 75% in two years, and (2) reduce the overall prevalence of infection by 50% in two years. A total of 4113 people were examined at least once during the two-year period. In the initial survey the highest proportion of infected individuals was in the 10-14-year age group, and in all subsequent surveys in the 5-9-year age group. The age group with the highest proportion of heavily infected individuals was 5-9 years for all surveys. The overall reduction of prevalence of infection from survey 1 to survey 4 was 52.9% and the prevalence of heavy infection was reduced by 62.2%. The conversion rates (negative to positive in two consecutive surveys) were highest in the longest interval of 12 months and the rates of reversion (positive to negative in two consecutive surveys, without a history of treatment) were highest in the shortest interval of 4 months. Some statistically significant relationships were observed between the number of doses and the egg reduction rates. However, for the egg-negative rates, no statistically significant relationship was observed. In the 4-month interval a 67.6% egg-negative rate was observed among those who took at least one dose; with the 12-month interval a 48.3% egg-negative rate was observed. Thus, selective population chemotherapy with metrifonate was shown to reduce the prevalence and intensity of infection due to S. haematobium over a 24-month period.

Biological control of the snail hosts of Schistosoma mansoni in the Caribbean area using Thiara spp.

Field observations and experiments using thiarid snails as competitors of Biomphalaria spp., potential intermediate hosts of Schistosoma mansoni in the Caribbean area, are reviewed. The parthenogenetic snails, Thiara granifera and T. (= Melanoides) tuberculata, were introduced to the Neotropical area in recent decades. In numerous islands and countries, these oriental species have demonstrated their capacity to colonize rapidly and densely many types of habitats while at the same time reducing and even eliminating populations of Biomphalaria spp. The results of field experiments, carried out in several Caribbean islands, have shown the efficiency as well as the limitations of T. tuberculata as a competitor of B. glabrata and B. straminea. In St. Lucia, B. glabrata was apparently eliminated from marshes and streams, 6 to 22 months after the introduction of the competitor. In Martinique, T. tuberculata was introduced into two groups of water-cress beds which constituted the last transmission sites of schistosomiasis on the island. In just less than three years after the introduction of the competitor, both B. glabrata and B. straminea have been eliminated from the transmission sites. In Guadeloupe, several introductions have been carried out in different types of habitat such as permanent ponds, canals, streams and temporary marshes. The findings of all field experiments have indicated that thiarid snails as competitors of pulmonates are favoured by the presence of permanent and stable habitats, preferably shallow, with emergent plants and well oxygenated. On the other hand, the competitor snails are at a disadvantage in waterbodies which are temporary, extremely deep, poorly oxygenated or with a dense mat of floating aquatic vegetation.(ABSTRACT TRUNCATED AT 250 WORDS)

Luque fixation to the sacral ala using the Dunn-McCarthy modification.

The Galveston-Luque technique of fixation to the pelvis requires solid bone and a strong pelvis. Because the majority of neuromuscular patients who require fixation to the pelvis have a weak and thin illum, an alternative to the Galveston technique was sought. A technique of rod contouring was developed that takes advantage of the reliable, stout bone of the sacral ala for fixation. Twenty-four patients have been instrumented with Luque rods and fused to the sacrum over the past 4 years using the technique. There have been no complications in this short follow-up.

Skeletal trauma in children.

In the area of skeletal injuries, i.e., fractures, as in all areas of care, children should not be treated as small adults. The immature, growing skeleton of the child results in both injuries and patterns of healing that are unique to this age group. These aspects of the immature skeleton and its effect on trauma in children are discussed in this article.

A locking collar for Luque rods.

The migration of hardware has been a problem in the Luque system of segmental spinal instrumentation. To prevent this migration, a device was designed to slip on the 3/16th inch or 1/4 inch Luque rod. This prevents movement between the wire-rod interface, stopping both distal and proximal rotation of the rod. This article reports 21 patients with neuromuscular scoliosis on whom this technique was used. There was no migration of hardware and only one wire breakage in an area separate from the locking collar. These results are a marked improvement from patients of previous reports who did not receive the new device. Laboratory testing on the locking collar determined the best location on the "L" rod to be in the middle third of the rod. Rod migration has essentially been eliminated with this technique.

Simultaneous bilateral avulsion fracture of the tibial tuberosity. A case report.

Bilateral avulsion fracture of the tibial tuberosity is a rare injury. A 14-year-old male gymnast sustained simultaneous tibial tuberosity displaced fractures while attempting a forward flip. The recommended treatment was open reduction and internal fixation. Functional results were excellent one year after surgical treatment.

Snail control in relation to a strategy for reduction of morbidity due to schistosomiasis.

The control of schistosomal disease is now distinctly feasible in endemic situations where a capable health care delivery system exists. Effective integrated control of schistosomiasis morbidity, within available resources at national level, is now being carried out in many countries. The control of snail hosts by chemical, environmental and/or biological means can still play a significant supporting role in many endemic situations. Today, however, as compared to earlier decades when disease control procedures were far less advanced, there is need for reappraisal of snail host control strategies to ensure that objectives are now correctly set, that the potential operational mechanisms are carefully chosen under the headings of desirability, feasibility and cost-effectiveness and that implementation and evaluation of the operations have, as far as possible, both theoretical and practical validity. Nowadays snail host control procedures must be intimately linked to knowledge of transmission sites and seasonal patterns, focal and periodic transmission being the rule rather than exception; in particular, they must be associated with local schemes for the delivery and evaluation of population based chemotherapy campaigns.

Ethiopian plants with proven and suspected molluscicidal activity: a new approach in plant evaluation.

Using available information on the toxicity, phytochemistry, ethnomedical uses and geographic distribution of plants, potentially suitable species are identified for the control of intermediate hosts of schistosomiasis in Ethiopia's lowlands where endod (Phytolacca dodecandra) is not available. Of 46 species with moderate to high snail-killing potency, 35 are indigenous to Ethiopia. They include 12 plant species with molluscicidal levels similar to those of endod, four of which are particularly suitable for snail control because of their low mammalian toxicity. Another 127 species indigenous to Ethiopia belong to genera with proven molluscicidal activity. The model for plant screening used here permits preliminary assessment of the suitability of plant resources in a given region or locality for snail control programs using existing data, without prior testing of local plants, making this approach appropriate for many developing countries.

Odynophagia in patients with malignant disorders.

The differential diagnosis of odynophagia in patients with malignant disorders usually includes esophagitis due to herpes, Candida, or gastroesophageal reflux. Two cases and a review of the literature are presented that illustrate that leukemic infiltration of the esophagus and necrosis of the esophageal mucosa following chemotherapy should be considered in addition to the more commonly recognized causes. Esophagoscopy with biopsy and brushing for fungal stains is essential for the correct diagnosis since the various causes for odynophagia may be clinically and radiographically indistinguishable.