RESUMO
Eight oligomenorrhoeic patients with increased luteinizing hormone (LH) and androgen levels who had failed to conceive during prolonged anti-oestrogen therapy received a new treatment. Large doses of an LH-releasing hormone (LHRH) analogue (HOE 766) were used to suppress circulating gonadotrophin concentrations and block the positive feedback gonadotrophin surge. Ovulation was induced during continued LHRH analogue treatment with exogenous gonadotrophins without interference from the patient's own pituitary. Seven of eight patients conceived rapidly without premature luteinization and without excessive ovarian enlargement. These complications had occurred in control treatment cycles using exogenous gonadotrophins in the absence of the LHRH analogue.
Assuntos
Busserrelina/uso terapêutico , Infertilidade Feminina/tratamento farmacológico , Hormônio Luteinizante/sangue , Menotropinas/uso terapêutico , Distúrbios Menstruais/tratamento farmacológico , Oligomenorreia/tratamento farmacológico , Adulto , Quimioterapia Combinada , Feminino , Hormônio Foliculoestimulante/sangue , Humanos , Infertilidade Feminina/complicações , Oligomenorreia/sangue , Oligomenorreia/complicações , Ovário/efeitos dos fármacos , Indução da OvulaçãoRESUMO
Non-stress antepartum fetal cardiotocographic tracings were obtained on 2268 occasions from 1084 'at risk' pregnancies, and the findings are assessed in 834 of these that were recorded within 7 days of delivery or fetal death. The baseline fetal heart rate, reactivity, baseline variability and the response to spontaneous uterine contractions have been related to the perinatal outcome. Poor or absent reactivity, reduced baseline variability and variable or late decelerations, in response to contractions, were useful indicators of fetal compromise, but baseline heart rate was less helpful. These abnormalities can occur individually, or in combination, and the different patterns so produced have been related to perinatal outcome.
Assuntos
Coração Fetal/fisiopatologia , Monitorização Fetal , Frequência Cardíaca , Complicações na Gravidez/fisiopatologia , Índice de Apgar , Eletrocardiografia , Feminino , Morte Fetal/fisiopatologia , Sofrimento Fetal/diagnóstico , Sofrimento Fetal/fisiopatologia , Humanos , Fonocardiografia , Gravidez , Risco , UltrassonografiaRESUMO
Three cases of perinatal paroxysmal supraventricular tachycardia are described. In two patients the tachycardia was present prior to delivery; in the third baby, who also had the Wolf-Parkinson-White Syndrome, the time of onset of tachycardia is not known. The risks of this condition to the foetus are largely unknown but severe intra-uterine cardiac failure can occur. Possible lines of management are discussed.
