1.
Gen Pharmacol
; 27(1): 109-11, 1996 Jan.
Artigo
em Inglês
| MEDLINE
| ID: mdl-8742505
RESUMO
1. Five oxazolidines were synthesized by reaction of (-) ephedrine with formaldehyde, propionaldehyde, butyraldehyde, isobutyraldehyde, and acetone, respectively. 2. Half-lives of hydrolysis were measured in pH 7.4 aqueous buffer. Half-lives varied from 12 seconds to 11 minutes. 3. The compounds were evaluated for their ability to increase locomotor activity in rats. All compounds significantly increased locomotor activity at 50 mg/kg dose. 4. The formaldehyde derivative had similar activity to (-) ephedrine. All other compounds were less active than (-) ephedrine.
Assuntos
Estimulantes do Sistema Nervoso Central/farmacologia , Efedrina/farmacologia , Atividade Motora/efeitos dos fármacos , Pró-Fármacos/farmacologia , Animais , Relação Dose-Resposta a Droga , Meia-Vida , Masculino , Ratos , Ratos Sprague-Dawley
2.
J Reform Jud
; 37(4): 49-58, 1990.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11831281