Telehealth for Comprehensive Care to Quarantine Residents: A Novel Approach and Lessons Learned.

Proactive engagement and care with regular and timely information are required to manage the health and well-being of people in quarantine. At Australia's Howard Springs International Quarantine Facility, a telehealth model was rapidly established using trained non-clinical Customer Service Officers (CSO's) with the aim to provide comprehensive care to residents, maximize staff safety, and reduce clinical workforce capacity pressures. We describe this model, whereby CSO's provided residents with daily COVID-19 symptom and well-being screening, weekly psychological screening, and ongoing linkage to additional clinical and administrative services. In addition, CSO's went beyond these duties to deliver personalized care through delivery of care packages and attendance of the departure point to farewell residents. From October 2020 to May 2021, across 7105 residents, we estimated that CSO's prevented over 75 000 face-to-face resident visits, which reduced workforce requirements and preserved staff safety through minimizing potential COVID-19 transmission and time spent in personal protective equipment in the challenging ambient environment. We share key lessons learned which may inform future telehealth models and guide a positive experience for quarantine residents.

Massive hepatic trematodosis in 5 juvenile bald eagles.

Hepatic trematodosis by opisthorchiid flukes has been reported sporadically in North American fish-eating raptors. Bald eagles (Haliaeetus leucocephalus) infected by these flukes often have various degrees of granulomatous cholangitis, pericholangitis, necrosis of adjacent hepatocytes, and subsequent hepatic fibrosis. Species identification has been complicated by the inability to dissect intact specimens from liver tissue. Between 2007 and 2018, 5 juvenile bald eagles with massive hepatic trematodosis were identified at autopsy. Histologically, flukes were non-spinous. Parasitologic identification revealed ventral suckers (80-93 µm diameter), and uteri containing golden, operculated eggs (~25.0 × 12.0 µm). An unfixed frozen liver sample of one eagle was analyzed by PCR and DNA sequencing targeting the large subunit rRNA, ITS region, and cox1 genes of the parasite. The fluke DNA sequences shared 99.6%, 98.4%, and 87.0% similarity, respectively, with Erschoviorchis anuiensis, a newly described opisthorchiid species infecting the liver and pancreas of fish-eating birds in Europe and Asia. Infection by E. anuiensis is highly pathogenic in several piscivorous bird species. The clinical significance of trematodosis in our 5 cases is uncertain because all birds had comorbidities.

Building a safety culture for infection prevention and control adherence at Howard Springs: A workplace survey.

BACKGROUND: Building a safety culture is essential to facilitate infection prevention and control (IPC) adherence in workplaces. We aimed to explore perceptions, barriers and facilitators to IPC procedures by the Australian Medical Assistance Team (AUSMAT) at Howard Springs International Quarantine Facility (HSIQF). METHODS: We performed a descriptive analysis of a cross-sectional survey administered to the AUSMAT employed at HSQIF from October 2020 to April 2021. We described motivation, training and compliance to IPC adherence and Likert scales described the level of agreement to the success of IPC procedures across the domains of communication, risk, trust, safety and environment, from the individual, team and organisational perspective. RESULTS: There were 101 participants (response rate 59%, 101/170) and 70% (71/101) were clinical. There was strong agreement to the success of IPC procedures, with a median 4 (agree) or 5 (strongly agree) across each domain and perspective of the 67 Likert items. Clinical staff reported slightly higher agreement than non-clinical staff across Likert items. To improve IPC compliance, most reported that daily training should be provided (77/97, 79%) and daily training was very or extremely effective (91/97, 93%). Participants were motivated by protecting self, friends, family and the community rather than workplace pressures. Barriers to IPC compliance were the ambient environment and fatigue. CONCLUSIONS: A safety culture was successfully built at HSQIF to optimise IPC adherence whilst managing multiple hazards including prevention of COVID-19 transmission. Strategies implemented by AUSMAT at the quarantine facility may inform the development of safety culture in other settings.

Electronic monitoring of doffing using video surveillance to minimise error rate and increase safety at Howard Springs International Quarantine Facility.

BACKGROUND: Safe donning and doffing of personal protective equipment (PPE) are critical to prevent transmission of infectious diseases. Novel strategies to improve infection prevention and control (IPC) adherence can optimise safety. We describe and quantify video surveillance of doffing at an outdoor hotel quarantine facility led by the Australian Medical Assistance Team in the Northern Territory, Australia. METHODS: Motion-activated video cameras were installed in seven areas where personnel doffed PPE upon exit from an area dedicated to quarantined residents. Video footage was reviewed daily and compliance issues were identified using a standardised checklist and risk graded to initiate feedback. We collated audit data from 1 February to 18 April 2021 to describe trends by month, staff group, doffing component and risk. RESULTS: In 235 h of video footage, 364 compliance issues were identified, of which none were considered high-risk compromising to PPE integrity. Compliance issues were low risk (55/364, 15%) or moderate risk (309/364, 85%) and the most common issue was missed or inadequate hand hygiene (156/364, 43%). Compliance issues per minute of video footage reviewed decreased following introduction of the activity, from 24 per 1000 in February to 7 per 1000 in March and April. CONCLUSION: Video surveillance with feedback supported rapid response to improve IPC adherence in a challenging ambient environment. The activity focused on perfection to identify compliance issues that would go unreported in most healthcare settings and contributed to a suit of activities that prevented any high-risk PPE breaches or compromises to safety.

An outdoor hotel quarantine facility model in Australia: best practice with optimal outcomes.

OBJECTIVE: To describe the operationalisation of a novel outdoor quarantine facility managed by the Australian Medical Assistance Team, the Howard Springs International Quarantine Facility (HSIQF) at the Centre for National Resilience in the Northern Territory, Australia. METHODS: We collated documentation and data from HSIQF to describe policies and procedures implemented and performed a descriptive analysis of key procedures and outcomes. RESULTS: From 23 October 2020 to 31 March 2021, 2.2% (129/5,987) of residents were confirmed COVD-19 cases. On average per day, 82 [Interquartile Range (IQR): 29-95] staff completed personal protective equipment (PPE) training, 94 [IQR: 90-104] staff completed antigen testing and 51 [IQR: 32-136] staff completed polymerase chain reaction testing. The operation focused on building a safe environment with infection prevention and control adherence and workforce sustainability. There was no leakage of SARS-CoV-2 to staff or the community and no PPE compromises requiring staff to quarantine for 14 days. CONCLUSION: HSIQF demonstrates the operationalisation of an effective, safe and replicable quarantine system. IMPLICATIONS FOR PUBLIC HEALTH: Quarantine is a critical public health tool for pandemic control. The HSIQF operations may be useful to inform the establishment and management of quarantine facilities for future and current disease outbreaks.

Genomic Evidence of In-Flight SARS-CoV-2 Transmission, India to Australia, April 2021.

Epidemiologic and genomic investigation of SARS-CoV-2 infections associated with 2 repatriation flights from India to Australia in April 2021 indicated that 4 passengers transmitted SARS-CoV-2 to >11 other passengers. Results suggest transmission despite mandatory mask use and predeparture testing. For subsequent flights, predeparture quarantine and expanded predeparture testing were implemented.

The dual-process perspective and the benefits of retrieval practice in younger and older adults.

The testing effect is often considered a recollection-related phenomenon. However, recent work has observed a benefit of testing to both recollection and familiarity on immediate and delayed final tests. Further, although aging populations show marked declines in recollection, older and younger adults often benefit similarly from testing. This finding suggests that the testing effect in older adults may function via relatively preserved familiarity and lends further support to the hypothesis that the testing effect does not function solely via recollection-related processes. The current study builds on this work to better understand the mechanisms from the dual-process perspective that underlie the testing effect in both younger and older adults. To this end, younger (18-22 year old) and older (65-82 year old) adults studied words, took cued-recall tests on half of the words, and took a final Remember-Know recognition test on all words immediately or after a 1-day delay. At both delays, older and younger adults exhibited a testing effect in both recollection and familiarity, although the magnitude of the testing effect in recollection was reduced for older relative to younger adults. Implications for theories of the testing effect and its application in older adult populations are explored.

Parallel hippocampal-parietal circuits for self- and goal-oriented processing.

The hippocampus is critically important for a diverse range of cognitive processes, such as episodic memory, prospective memory, affective processing, and spatial navigation. Using individual-specific precision functional mapping of resting-state functional MRI data, we found the anterior hippocampus (head and body) to be preferentially functionally connected to the default mode network (DMN), as expected. The hippocampal tail, however, was strongly preferentially functionally connected to the parietal memory network (PMN), which supports goal-oriented cognition and stimulus recognition. This anterior-posterior dichotomy of resting-state functional connectivity was well-matched by differences in task deactivations and anatomical segmentations of the hippocampus. Task deactivations were localized to the hippocampal head and body (DMN), relatively sparing the tail (PMN). The functional dichotomization of the hippocampus into anterior DMN-connected and posterior PMN-connected parcels suggests parallel but distinct circuits between the hippocampus and medial parietal cortex for self- versus goal-oriented processing.

Are efficient learners of verbal stimuli also efficient and precise learners of visuospatial stimuli?

People differ in how quickly they learn information and how long they remember it, and these two variables are correlated such that people who learn more quickly tend to retain more of the newly learned information. Zerr and colleagues [2018. Learning efficiency: Identifying individual differences in learning rate and retention in healthy adults. Psychological Science, 29(9), 1436-1450] termed the relation between learning rate and retention as learning efficiency, with more efficient learners having both a faster acquisition rate and better memory performance after a delay. Zerr et al. also demonstrated in separate experiments that how efficiently someone learns is stable across a range of days and years with the same kind of stimuli. The current experiments (combined N = 231) replicate the finding that quicker learning coincides with better retention and demonstrate that the correlation extends to multiple types of materials. We also address the generalisability of learning efficiency: A person's efficiency with learning Lithuanian-English (verbal-verbal) pairs predicts their efficiency with Chinese-English (visuospatial-verbal) and (to a lesser extent) object-location (visuospatial-visuospatial) paired associates. Finally, we examine whether quicker learners also remember material more precisely by using a continuous measure of recall accuracy with object-location pairs.

The stability of visual perspective and vividness during mental time travel.

When remembering or imagining, people can experience an event from their own eyes, or as an outside observer, with differing levels of vividness. The perspective from, and vividness with, which a person remembers or imagines has been related to numerous individual difference characteristics. These findings require that phenomenology during mental time travel be trait-like-that people consistently experience similar perspectives and levels of vividness. This assumption remains untested. Across two studies (combined N = 295), we examined the stability of visual perspective and vividness across multiple trials and timepoints. Perspective and vividness showed weak within-session stability when reported across just a few trials but showed strong within-session stability when sufficient trials were collected. Importantly, both visual perspective and vividness demonstrated good-to-excellent across-session stability across different delay intervals (two days to six weeks). Overall, our results suggest that people dependably experience similar visual phenomenology across occurrences of mental time travel.

Practicing Retrieval Facilitates Learning.

How do we go about learning new information? This article reviews the importance of practicing retrieval of newly experienced information if one wants to be able to retrieve it again in the future. Specifically, practicing retrieval shortly after learning can slow the forgetting process. This benefit can be seen across various material types, and it seems prevalent in all ages and learner abilities and on all types of test. It can also be used to enhance student learning in a classroom setting. I review theoretical understanding of this phenomenon (sometimes referred to as the testing effect or as retrieval-based learning) and consider directions for future research.

Individual-specific functional connectivity of the amygdala: A substrate for precision psychiatry.

The amygdala is central to the pathophysiology of many psychiatric illnesses. An imprecise understanding of how the amygdala fits into the larger network organization of the human brain, however, limits our ability to create models of dysfunction in individual patients to guide personalized treatment. Therefore, we investigated the position of the amygdala and its functional subdivisions within the network organization of the brain in 10 highly sampled individuals (5 h of fMRI data per person). We characterized three functional subdivisions within the amygdala of each individual. We discovered that one subdivision is preferentially correlated with the default mode network; a second is preferentially correlated with the dorsal attention and fronto-parietal networks; and third subdivision does not have any networks to which it is preferentially correlated relative to the other two subdivisions. All three subdivisions are positively correlated with ventral attention and somatomotor networks and negatively correlated with salience and cingulo-opercular networks. These observations were replicated in an independent group dataset of 120 individuals. We also found substantial across-subject variation in the distribution and magnitude of amygdala functional connectivity with the cerebral cortex that related to individual differences in the stereotactic locations both of amygdala subdivisions and of cortical functional brain networks. Finally, using lag analyses, we found consistent temporal ordering of fMRI signals in the cortex relative to amygdala subdivisions. Altogether, this work provides a detailed framework of amygdala-cortical interactions that can be used as a foundation for models relating aberrations in amygdala connectivity to psychiatric symptoms in individual patients.

Interpersonal violence and violent re-injury in the Northern Territory.

OBJECTIVES: To analyse incidence of prior emergency department presentations for interpersonal violence and demographics for a series of hospital admissions for interpersonal violence injuries. DESIGN: Retrospective analysis of trauma registry. SETTING: A tertiary hospital and primary referral centre for trauma in the Top End of the Northern Territory. PARTICIPANTS: Patients hospitalised from 2010 to 2015 for injuries due to interpersonal violence with an injury severity score > 9. MAIN OUTCOME MEASURES: Patient demographics, injury location, assault mechanism, alleged perpetrator, time/day of event, alcohol involvement, clinical outcome and prior emergency department presentations for interpersonal violence. RESULTS: A total of 248 admissions for patients with Injury Severity Score > 9 due to interpersonal violence were identified. Indigenous females over-represented non-Indigenous females (35.4% vs 5.0%, P < .001). The majority of victims had evidence of alcohol intake at presentation. Victims of single-punch head injuries were mostly male and non-Indigenous, whilst Indigenous persons experienced significantly more blunt and penetrating weapon injuries (66.7% and 68.1%). Forty-three per cent of patients had a preceding emergency department presentation for interpersonal violence; female gender, Indigenous ethnicity, evidence of alcohol intake, and urban location of injury were independent risk factors for prior interpersonal violence presentation. CONCLUSIONS: Interpersonal violence is a recurring disease for a just under half of those presenting to a Top End hospital with moderate to severe injuries. Indigenous ethnicity, female gender and evidence of alcohol intake are predictive of prior interpersonal violence presentations. Patient under-reporting and incomplete data may underestimate the true prevalence of interpersonal violence presentations in rural and remote locales.

Quad bike injuries at an Australian regional hospital: a trauma registry review.

BACKGROUND: Quad bikes are a prominent cause of morbidity and mortality in Australia in both agriculture and recreation. This study describes the clinical and epidemiological characteristics of quad bike injuries at the Royal Darwin Hospital (RDH). METHODS: A retrospective review of the RDH Trauma Registry for all quad bike mechanism of injury from 1 January 2006 to 31 December 2015 was conducted. We analysed patient demographics, remoteness of injury, injury circumstances, patterns and severity of injury, surgical intervention, length of stay and outcome. RESULTS: In total, 186 persons were injured, of whom 81% (n = 150) were male. There was an increase in quad bike incidents during the 10-year study period, and the greatest increase was seen in the 16-30 years age group. When helmet use was recorded, it was low at 36% (n = 47). Alcohol involvement was 40% (n = 74). Cases with alcohol involvement were 10 times less likely to have worn a helmet than those cases without alcohol involvement (95% confidence interval 3.8-29). The median Injury Severity Score was 8 (interquartile range 4-10). The median hospital length of hospital stay was 4 days (interquartile range 3-7). The majority, 57% (n = 106), did not require surgical intervention. The fatality rate was <5%. CONCLUSION: Quad bike incidents presenting to RDH are increasing. This likely corresponds to the increased number of quad bikes in circulation, and has resulted in an increased demand on health care. Alcohol use and a lack of safety equipment continue to be potentially correctable factors.

Integrative and Network-Specific Connectivity of the Basal Ganglia and Thalamus Defined in Individuals.

The basal ganglia, thalamus, and cerebral cortex form an interconnected network implicated in many neurological and psychiatric illnesses. A better understanding of cortico-subcortical circuits in individuals will aid in development of personalized treatments. Using precision functional mapping-individual-specific analysis of highly sampled human participants-we investigated individual-specific functional connectivity between subcortical structures and cortical functional networks. This approach revealed distinct subcortical zones of network specificity and multi-network integration. Integration zones were systematic, with convergence of cingulo-opercular control and somatomotor networks in the ventral intermediate thalamus (motor integration zones), dorsal attention and visual networks in the pulvinar, and default mode and multiple control networks in the caudate nucleus. The motor integration zones were present in every individual and correspond to consistently successful sites of deep brain stimulation (DBS; essential tremor). Individually variable subcortical zones correspond to DBS sites with less consistent treatment effects, highlighting the importance of PFM for neurosurgery, neurology, and psychiatry.

A role for familiarity in supporting the testing effect over time.

Endel Tulving (1985) drew a distinction between Remembering and Knowing, spurring a great deal of research on the memorial experiences of recollection and familiarity and their contribution to various phenomena in memory. More recently, studies have used this distinction to situate our understanding of the processes that contribute to the testing effect-or, the benefit of retrieval practice to later memory (see also Tulving, 1967). Using retention intervals of approximately 15 min or less between initial and final testing, several studies have found that initial testing magnifies estimates of recollection but not familiarity, regardless of whether a testing effect is revealed in overall recognition performance (Chan and McDermott, 2007). However, the efficacy of prior testing in enhancing memory has been shown to change over time, as have estimates of recollection and familiarity. Thus, the mechanisms that underlie the quintessential testing effect-one that occurs in overall recognition or recall over longer delays-are still uncertain. To investigate this issue, in two experiments, subjects studied word lists, took 3-letter stem cued-recall tests on half of the studied words, and completed a final recognition test in which estimates of recollection and familiarity were obtained via confidence (Experiment 1) or Remember-Know-New (Experiment 2) judgments. Critically, final recognition tests occurred either immediately, 1 day (Experiment 1 only), or 4 days after initial learning. At all retention intervals and in both methods of estimating recollection and familiarity on the final test (i.e. receiver-operating characteristic and remember-know analyses), initial testing magnified estimates of both recollection and familiarity. These findings suggest that the testing effect can result from changes in both processes and pose issues for theories of the testing effect that consider an exclusive role for recollection.

Trait-like variants in human functional brain networks.

Resting-state functional magnetic resonance imaging (fMRI) has provided converging descriptions of group-level functional brain organization. Recent work has revealed that functional networks identified in individuals contain local features that differ from the group-level description. We define these features as network variants. Building on these studies, we ask whether distributions of network variants reflect stable, trait-like differences in brain organization. Across several datasets of highly-sampled individuals we show that 1) variants are highly stable within individuals, 2) variants are found in characteristic locations and associate with characteristic functional networks across large groups, 3) task-evoked signals in variants demonstrate a link to functional variation, and 4) individuals cluster into subgroups on the basis of variant characteristics that are related to differences in behavior. These results suggest that distributions of network variants may reflect stable, trait-like, functionally relevant individual differences in functional brain organization.

High-fidelity mapping of repetition-related changes in the parietal memory network.

fMRI studies of human memory have identified a "parietal memory network" (PMN) that displays distinct responses to novel and familiar stimuli, typically deactivating during initial encoding but robustly activating during retrieval. The small size of PMN regions, combined with their proximity to the neighboring default mode network, makes a targeted assessment of their responses in highly sampled subjects important for understanding information processing within the network. Here, we describe an experiment in which participants made semantic decisions about repeatedly-presented stimuli, assessing PMN BOLD responses as items transitioned from experimentally novel to repeated. Data are from the highly-sampled subjects in the Midnight Scan Club dataset, enabling a characterization of BOLD responses at both the group and single-subject level. Across all analyses, PMN regions deactivated in response to novel stimuli and displayed changes in BOLD activity across presentations, but did not significantly activate to repeated items. Results support only a portion of initially hypothesized effects, in particular suggesting that novelty-related deactivations may be less susceptible to attentional/task manipulations than are repetition-related activations within the network. This in turn suggests that novelty and familiarity may be processed as separable entities within the PMN.

Burn injury as a result of interpersonal violence in the Northern Territory Top End.

AIM: To describe the demographics, circumstances, burn wound characteristics and current tertiary centre management of interpersonal violence (IPV) burn victims in the Northern Territory Top End. It is anticipated that such knowledge gained will be of benefit to key stakeholders across the spectrum of injury prevention and management in this region. METHODS: All adult admissions to the Royal Darwin Hospital (RDH) during 2010-2015 were identified through the Burns Registry of Australia and New Zealand. Demographic and burn characteristics were compared between those classified as IPV and non-IPV. Case note review provided supplementary data for the IPV subset. RESULTS: Fifty-three patients met IPV criteria, comprising 7.4% of admissions to the RDH Burn Service. IPV burn victims were 2.3 times more likely to be female than those with non-IPV burn (95% CI: 1.2-4.3), and 17 times more likely to be Indigenous (95% CI: 7.9-35). Approximately half (53%) of IPV burns were classified as family or domestic violence; scalding was the most common mechanism in this group. Ten patients (19%) had incomplete burn care through self-discharge, all identified as Indigenous. Twenty percent of patients had no documented inpatient psychosocial support. CONCLUSIONS: Female and Indigenous persons are at increased risk of IPV burn. The challenges of providing care to the IPV burn population extend beyond burn wound closure.