RESUMO
BACKGROUND AND OBJECTIVE: The authors studied the efficacy and complications of intraoperative mitomycin-C in glaucoma associated with ocular inflammation. PATIENTS AND METHODS: The authors retrospectively reviewed the medical records of 24 consecutive patients (24 eyes) with glaucoma and ocular inflammation who had been treated with trabeculectomy and intraoperative mitomycin-C. Patient ages ranged from 10 to 83 years (mean 43 years). All patients were observed for at least 6 months. RESULTS: With a mean follow-up time of 14.6 months, 18 of the 24 patients (75%) retained vision and had an intraocular pressure of 21 mm Hg or lower with or without medications (range 4 to 21 mm Hg; mean 13.4 mm Hg). Fifteen of 24 patients (62%) had an intraocular pressure of 21 mm Hg or lower with no medications. Three patients required tube shunt implants. One patient had a retinal detachment and lost light perception. One patient had endophthalmitis 14 months after surgery. Seven of 24 patients lost two or more lines of Snellen acuity. CONCLUSION: Trabeculectomy with mitomycin-C can control intraocular pressure in glaucoma associated with ocular inflammation, but complications are frequent.
Assuntos
Antibióticos Antineoplásicos/administração & dosagem , Glaucoma/terapia , Mitomicina/administração & dosagem , Trabeculectomia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Quimioterapia Adjuvante , Criança , Feminino , Seguimentos , Glaucoma/complicações , Humanos , Pressão Intraocular , Cuidados Intraoperatórios , Masculino , Pessoa de Meia-Idade , Soluções Oftálmicas , Complicações Pós-Operatórias , Estudos Retrospectivos , Resultado do Tratamento , Uveíte/complicações , Uveíte/terapiaRESUMO
Snoring, widespread in this country, has important social and interpersonal ramifications. It may be a symptom of serious associated disorders, or it may be a health hazard in and of itself. The pathophysiology is related to loose vibrating tissue in the pharynx and is often associated with obesity. The assessment of snoring may include polysomnography if symptoms suggest air flow disruption and/or sleep fragmentation. Treatment options include behavioral therapeutic measures as well as surgical approaches. It is important to differentiate primary snoring from OSA and other sleep-related breathing disorders before embarking on surgical intervention.
Assuntos
Ronco/epidemiologia , Humanos , Palato Mole/cirurgia , Faringe/fisiopatologia , Respiração com Pressão Positiva , Prevalência , Respiração , Ronco/cirurgia , Ronco/terapia , Úvula/cirurgiaRESUMO
In a prospective study from May 1971 to November 1973, 20 consecutive patients with a diagnosis of disseminated cryptococcosis were treated for six weeks with a combination of amphotericin B (20 mg daily) intravenously and flucytosine (150 mg/kg daily) orally. Fifteen patients has culturally docummented Cryptococcus neoformans meningitis, and three died of infection early in therapy. Of the remaining 12 patients, eight were alive and well eight to 34 months after therapy, and four died of other causes. None of the surviving patients has relapsed. Hematologic complications developed in nine patients, three of whom had no underlying lymphoreticular disorder or therapy with known cytotoxic agents. Renal insufficiency of mild degree occurred in only six patients. A shorter period of hospitalization and reduction in toxicity of amphotericin B suggest that combined therapy is a safe and efficacious alternative to other regimens.
