RESUMO
The first experimental study of a coaxial free-electron maser (FEM) based on two-dimensional (2D) distributed feedback is presented. A new type of cavity formed with coaxial 2D surface photonic band gap structures was used. The FEM was driven by a large diameter (7 cm), high-current (500 A), annular electron beam of energy 475 keV. By tuning the amplitude of the undulator or guide magnetic field, modes associated with the different band gaps of the 2D structures were excited. The -band coaxial FEM generated 15 MW of radiation with a 6% conversion efficiency, in excellent agreement with theory.
RESUMO
Many systemically effective drugs such as cyclosporin A are ineffective topically because of their poor penetration into skin. To surmount this problem, we conjugated a heptamer of arginine to cyclosporin A through a pH-sensitive linker to produce R7-CsA. In contrast to unmodified cyclosporin A, which fails to penetrate skin, topically applied R7-CsA was efficiently transported into cells in mouse and human skin. R7-CsA reached dermal T lymphocytes and inhibited cutaneous inflammation. These data establish a general strategy for enhancing delivery of poorly absorbed drugs across tissue barriers and provide a new topical approach to the treatment of inflammatory skin disorders.
