RESUMO
BACKGROUND: Increased concentrations of haptoglobin (Hp), a moderate acute phase protein, have been demonstrated in dogs with hyperadrenocorticism (HAC). Monitoring serum concentrations of Hp in hyperadrenocorticoid dogs before and after trilostane administration may provide valuable information on the response to therapy. OBJECTIVE: The aim of this study was to measure Hp concentrations in dogs with spontaneously occurring HAC at the time of diagnosis and after treatment with trilostane. METHODS: Serum Hp concentration was measured using an automatic biochemical assay based on Hp-hemoglobin binding and utilizing SB-7 reagent in 12 dogs with spontaneous HAC before and after treatment with trilostane (30 or 60 mg PO q 12-24 h). Post-treatment Hp concentrations were measured at the time the owner reported an improvement in clinical signs. Pretreatment and post-treatment Hp values were compared with reference values and with values from 4 healthy control dogs. RESULTS: Two dogs with HAC had pretreatment Hp values within the reference interval; 10 dogs had moderate (n = 8) or marked (n = 2) increases in Hp concentration. After treatment with trilostane, Hp concentration remained within the reference interval (n = 2), decreased to within the reference interval (n = 3), or remained moderately increased (n = 7; 3-10 g/L). Overall, a significant decrease was observed in Hp concentration after trilostane treatment compared with pretreatment values (P <.005). Both untreated and treated dogs with HAC had significantly higher Hp concentrations (P <.001) when compared with control dogs. CONCLUSIONS: Clinical control of HAC did not closely relate to serum Hp concentration. Further studies are required to assess whether this is because of inadequate control of disease or because a build-up of cortisol precursors or secondary effects of HAC affect Hp concentration.
Assuntos
Hiperfunção Adrenocortical/veterinária , Di-Hidrotestosterona/análogos & derivados , Doenças do Cão/tratamento farmacológico , Inibidores Enzimáticos/uso terapêutico , Haptoglobinas/metabolismo , Hiperfunção Adrenocortical/sangue , Hiperfunção Adrenocortical/tratamento farmacológico , Animais , Di-Hidrotestosterona/uso terapêutico , Doenças do Cão/sangue , Cães , Valores de ReferênciaAssuntos
Cardiomiopatia Dilatada/veterinária , Doenças do Gato/diagnóstico , Insuficiência Cardíaca/veterinária , Animais , Cardiomiopatia Dilatada/complicações , Cardiomiopatia Dilatada/diagnóstico , Doenças do Gato/diagnóstico por imagem , Doenças do Gato/patologia , Doenças do Gato/terapia , Gatos , Diagnóstico Diferencial , Digoxina/administração & dosagem , Enalapril/administração & dosagem , Furosemida/administração & dosagem , Insuficiência Cardíaca/diagnóstico , Insuficiência Cardíaca/etiologia , Masculino , Nitroglicerina/administração & dosagem , Oxigenoterapia , Radiografia , UltrassonografiaRESUMO
A one-year-old, neutered female Skye terrier presented with anorexia, vomiting, seizures and ascites. Portal venography demonstrated the presence of multiple acquired portosystemic shunts. Hepatic biopsy confirmed the presence of copper accumulation and fibrosis. Treatment included ursodeoxycholic acid therapy, colchicine and oral zinc. To the authors' knowledge, this is the first case report detailing successful management of Skye terrier hepatopathy.
Assuntos
Cobre/metabolismo , Doenças do Cão/diagnóstico , Doenças do Cão/tratamento farmacológico , Hepatopatias/veterinária , Animais , Ascite/etiologia , Ascite/veterinária , Colchicina/administração & dosagem , Doenças do Cão/diagnóstico por imagem , Doenças do Cão/patologia , Cães , Quimioterapia Combinada , Feminino , Fígado/irrigação sanguínea , Hepatopatias/complicações , Hepatopatias/diagnóstico , Hepatopatias/tratamento farmacológico , Radiografia , Convulsões/etiologia , Convulsões/veterinária , Ultrassonografia , Ácido Ursodesoxicólico/administração & dosagem , Vômito/etiologia , Vômito/veterinária , Zinco/administração & dosagemRESUMO
A three-year-old, male neutered domestic shorthair cat was presented with dysphagia and regurgitation following treatment with oral doxycycline and oxytetracycline for Haemobartonella felis infection. Fluoroscopy confirmed the presence of multiple strictures along the entire length of the oesophagus. Balloon dilatation was performed successfully on two occasions and the symptoms resolved. To the authors' knowledge, this is the first report of oesophageal strictures associated with oral administration of tetracyclines in a cat in the UK.
