1.
Pediatr Rev
; 21(7): 250-2, 2000 Jul.
Artigo
em Inglês
| MEDLINE
| ID: mdl-10878191
2.
Cell
; 82(5): 773-83, 1995 Sep 08.
Artigo
em Inglês
| MEDLINE
| ID: mdl-7671305
RESUMO
We have identified a target antigen in autoimmune cerebellar degeneration, beta-NAP, that is closely related to the beta-adaptin and beta-COP coat proteins. Beta-NAP is a nonclathrin-associated phosphoprotein expressed exclusively in neurons, from E12 through adulthood. Beta-NAP is present in the neuronal soma and nerve terminal as soluble and membrane-bound pools and is associated with a discrete set of nerve-terminal vesicles. These results establish beta-NAP as a neuron-specific vesicle coat protein. We propose a model in which beta-NAP mediates vesicle transport between the soma and the axon terminus and suggest that beta-NAP may represent a general class of coat proteins that mediates apical transport in polarized cells.