RESUMO
The effects of bilateral microinjections of a new potent and highly selective delta-opioid receptor agonist pCl-DPDPE (0.00, 0.1, 1.0, or 2.5 micrograms/side) were tested in rats for 60 min in activity monitors. The durations of horizontal movement time, rearing time, and stereotypy time were measured during six consecutive 10-min time blocks. The pCl-DPDPE resulted in short-lived biphasic effects of attenuation followed by potentiation for the three measures. These data in part replicate the behavioral effects of other delta-opioid receptor agonists.
Assuntos
Analgésicos/farmacologia , Encefalinas/farmacologia , Atividade Motora/efeitos dos fármacos , Núcleo Accumbens , Receptores Opioides delta/agonistas , Analgésicos/administração & dosagem , Animais , Relação Dose-Resposta a Droga , D-Penicilina (2,5)-Encefalina , Encefalinas/administração & dosagem , Injeções , Masculino , Núcleo Accumbens/anatomia & histologia , Ratos , Comportamento Estereotipado/efeitos dos fármacos , Fatores de TempoRESUMO
The central effects of mu-opioid receptor agonist DALDA (ICV 0.00, 0.1, or 1.0 micrograms) were investigated in rats for 120 min on activity monitors. The durations in seconds of horizontal movement time, rearing time, and stereotypy time were measured during 12 consecutive 10-min time blocks. DALDA (ICV, 0.1 and 1.0 micrograms) resulted in biphasic effects, inhibition followed by activation for horizontal movement, rearing, and stereotypy times.
Assuntos
Analgésicos/farmacologia , Locomoção/efeitos dos fármacos , Oligopeptídeos/farmacologia , Receptores Opioides mu/agonistas , Sequência de Aminoácidos , Analgésicos/administração & dosagem , Animais , Injeções Intraventriculares , Masculino , Dados de Sequência Molecular , Atividade Motora/efeitos dos fármacos , Oligopeptídeos/administração & dosagem , Ratos , Comportamento Estereotipado/efeitos dos fármacosRESUMO
The effects of bilateral microinjections of mu-opioid receptor agonist DAMGO (0.00, 0.01, 0.1, or 1.0 microgram/side) were tested in rats for 120 min in activity monitors. The horizontal movement, rearing, and stereotypy times in seconds were measured during 12 consecutive 10-min time blocks. DAMGO (0.01, 0.1, and 1.0 microgram) resulted in biphasic effects, inhibition followed by activation for each of the three measures. These data replicate the behavioral effects of ICV DAMGO except that the duration of the behavioral effects were longer with Acb injections.
Assuntos
Encefalinas/administração & dosagem , Atividade Motora/efeitos dos fármacos , Núcleo Accumbens/efeitos dos fármacos , Receptores Opioides mu/efeitos dos fármacos , Sequência de Aminoácidos , Animais , Ala(2)-MePhe(4)-Gly(5)-Encefalina , Encefalinas/química , Masculino , Microinjeções , Dados de Sequência Molecular , Atividade Motora/fisiologia , Núcleo Accumbens/fisiologia , Ratos , Receptores Opioides mu/fisiologia , Comportamento Estereotipado/efeitos dos fármacos , Comportamento Estereotipado/fisiologiaRESUMO
Postpartum, presuckle, colostrum samples were collected from 100 mares. Colostral specific gravities significantly correlated (r = 0.9) with colostral immunoglobulin (Ig)G concentrations. Foal serum IgG concentrations highly correlated (r = 0.82) with specific gravities of the colostrum each foal ingested. Eight of 48 foals (17%) had serum IgG concentrations less than 400 mg/dl. The dams of these 8 foals had colostral sp gr less than 1.06 and colostral IgG concentrations less than 3,000 mg/dl. Foals had serum IgG concentrations greater than 520 mg/dl 24 hours after parturition, when the colostral specific gravity of the dam was greater than or equal to 1.06. Effects of breed on colostral specific gravity, colostral IgG concentrations, foal serum IgG concentrations, and mare serum IgG concentrations were not significant.
