RESUMO
The clinical and pathological features, including ultrastructural and immunocytochemical findings, of 2 cases of primary malignant fibrous histiocytoma of the uterus are reported. One patient had pulmonary metastases at the time of hysterectomy: she developed pelvic recurrence and died 3 mth after operation. The other patient was well and apparently free of disease 6 mth after hysterectomy. Histologically both tumours resembled pleomorphic leiomyosarcoma, and the diagnosis of a malignant fibrous histiocytoma was confirmed only after electron microscopic and immunocytochemical studies. Hormone receptor assay for estrogen and progesterone was positive in both tumours. Anti-estrogen treatment was started in one case but was ineffective.
Assuntos
Histiocitoma Fibroso Benigno/patologia , Neoplasias Uterinas/patologia , Idoso , Feminino , Histiocitoma Fibroso Benigno/ultraestrutura , Humanos , Técnicas Imunoenzimáticas , Pessoa de Meia-Idade , Neoplasias Uterinas/ultraestruturaRESUMO
114 biopsy specimens from 70 patients with ovarian carcinoma at all stages of disease were submitted for assessment of clonogenic capacity in agar. A highly significant correlation was found between agar clonogenicity and patient survival after biopsy. However, problems related to inherent tumour heterogeneity, quality of sample and tissue disaggregation indicate that this technique may have limited applicability in the routine assessment of patients. Only 41 biopsy specimens (36%) from 31 patients (44.3%) complied with the prerequisite criteria for agar clonogenic assessment, namely: (a) the confirmed presence of malignant cells in the biopsy, (b) the ability to prepare a single-cell suspension, and (c) adequate viable cell numbers for assay. Furthermore, although the dominant patterns of agar clonogenic growth could be identified and correlated with stage of disease, the heterogeneity in both initial clonogenic capacity and "self-renewal" capacity assessed by the ability of primary clones to propagate in liquid culture and reclone in agar was too inconsistent for the assay to be used as a prognostic index for the individual patient.
Assuntos
Neoplasias Ovarianas/patologia , Ágar , Biópsia , Células Clonais , Feminino , Humanos , Neoplasias Ovarianas/mortalidade , PrognósticoAssuntos
Complicações do Trabalho de Parto/terapia , Prolapso Uterino/terapia , Adulto , Feminino , Humanos , Métodos , GravidezAssuntos
Neoplasias Ovarianas/cirurgia , Adulto , Castração , Cistadenoma/cirurgia , Feminino , Humanos , Histerectomia , Pessoa de Meia-IdadeRESUMO
A method is described for the production of an ejaculate the paraplegic male by electrical stimulation from a probe placed in the rectum. A case is reported in which an ejaculate produced by this method was used to inseminate the wife of a paraplegic patient. Pregnancy resulted, but the infant died. Post-mortem examination revealed the presence of transposition of the great vessels.
