Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 23
Filtrar
Mais filtros










Base de dados
Intervalo de ano de publicação
1.
Epidemiol Psychiatr Sci ; 30: e22, 2021 Mar 10.
Artigo em Inglês | MEDLINE | ID: mdl-33750482

RESUMO

AIMS: Mental health (MH) service users have increased prevalence of chronic physical conditions such as cardio-respiratory diseases and diabetes. Potentially Preventable Hospitalisations (PPH) for physical health conditions are an indicator of health service access, integration and effectiveness, and are elevated in long term studies of people with MH conditions. We aimed to examine whether PPH rates were elevated in MH service users over a 12-month follow-up period more suitable for routine health indicator reporting. We also examined whether MH service users had increased PPH rates at a younger age, potentially reflecting the younger onset of chronic physical conditions. METHODS: A population-wide data linkage in New South Wales (NSW), Australia, population 7.8 million. PPH rates in 178 009 people using community MH services in 2016-2017 were compared to population rates. Primary outcomes were crude and age- and disadvantage-standardised annual PPH episode rate (episodes per 100 000 population), PPH day rate (hospital days per 100 000) and adjusted incidence rate ratios (AIRR). RESULTS: MH service users had higher rates of PPH admission (AIRR 3.6, 95% CI 3.5-3.6) and a larger number of hospital days (AIRR 5.2, 95% CI 5.2-5.3) than other NSW residents due to increased likelihood of admission, more admissions per person and longer length of stay. Increases were greatest for vaccine-preventable conditions (AIRR 4.7, 95% CI 4.5-5.0), and chronic conditions (AIRR 3.7, 95% CI 3.6-3.7). The highest number of admissions and relative risks were for respiratory and metabolic conditions, including chronic obstructive airways disease (AIRR 5.8, 95% CI 5.5-6.0) and diabetic complications (AIRR 5.4, 95% CI 5.1-5.8). One-quarter of excess potentially preventable bed days in MH service users were due to vaccine-related conditions, including vaccine-preventable respiratory illness. Age-related increases in risk occurred earlier in MH service users, particularly for chronic and vaccine-preventable conditions. PPH rates in MH service users aged 20-29 were similar to population rates of people aged 60 and over. These substantial differences were not explained by socio-economic disadvantage. CONCLUSIONS: PPHs for physical health conditions are substantially increased in people with MH conditions. Short term (12-month) PPH rates may be a useful lead indicator of increased physical morbidity and less accessible, integrated or effective health care. High hospitalisation rates for vaccine-preventable respiratory infections and hepatitis underline the importance of vaccination in MH service users and suggests potential benefits of prioritising this group for COVID-19 vaccination.


Assuntos
COVID-19/epidemiologia , Serviços Comunitários de Saúde Mental/estatística & dados numéricos , Hospitalização/estatística & dados numéricos , SARS-CoV-2 , Adulto , Idoso , Austrália , Vacinas contra COVID-19 , Doença Crônica/epidemiologia , Comorbidade , Nível de Saúde , Humanos , Pessoa de Meia-Idade , New South Wales/epidemiologia , Prevalência , Adulto Jovem
5.
J Am Vet Med Assoc ; 216(12): 1904-10, 2000 Jun 15.
Artigo em Inglês | MEDLINE | ID: mdl-10863585
6.
Biochemistry ; 39(15): 4533-42, 2000 Apr 18.
Artigo em Inglês | MEDLINE | ID: mdl-10758003

RESUMO

The conversion of inosine 5'-monophosphate (IMP) to xanthosine 5'-monophosphate (XMP) is the committed and rate-limiting reaction in de novo guanine nucleotide biosynthesis. Inosine 5'- monophosphate dehydrogenase (IMPDH) is the enzyme that catalyzes the oxidation of IMP to XMP with the concomitant reduction of nicotinamide adenine dinucleotide (from NAD(+) to NADH). Because of its critical role in purine biosynthesis, IMPDH is a drug design target for anticancer, antiinfective, and immunosuppressive chemotherapy. We have determined the crystal structure of IMPDH from Borrelia burgdorferi, the bacterial spirochete that causes Lyme disease, with a sulfate ion bound in the IMP phosphate binding site. This is the first structure of IMPDH in the absence of substrate or cofactor where the active-site loop (loop 6), which contains the essential catalytic residue Cys 229, is clearly defined in the electron density. We report that a seven residue region of loop 6, including Cys229, is tilted more than 6 A away from its position in substrate- or substrate analogue-bound structures of IMPDH, suggestive of a conformational change. The location of this loop between beta6 and alpha6 links IMPDH to a family of beta/alpha barrel enzymes known to utilize this loop as a functional lid during catalysis. Least-squares minimization, root-mean-square deviation analysis, and inspection of the molecular surface of the loop 6 region in the substrate-free B. burgdorferi IMPDH and XMP-bound Chinese hamster IMPDH show that loop 6 follows a similar pattern of hinged rigid-body motion and indicates that IMPDH may be using loop 6 to bind and sequester substrate and to recruit an essential catalytic residue.


Assuntos
Grupo Borrelia Burgdorferi/enzimologia , IMP Desidrogenase/química , IMP Desidrogenase/metabolismo , Movimento (Física) , Sequência de Aminoácidos , Animais , Sítios de Ligação , Domínio Catalítico , Cristalografia por Raios X , Cisteína/química , Cisteína/metabolismo , Desenho de Fármacos , Humanos , Inosina Monofosfato/metabolismo , Modelos Moleculares , Dados de Sequência Molecular , NAD/metabolismo , Maleabilidade , Conformação Proteica , Ribonucleotídeos/metabolismo , Alinhamento de Sequência , Solventes , Eletricidade Estática , Relação Estrutura-Atividade , Sulfatos/metabolismo , Xantina
10.
J Clin Pathol ; 51(6): 467-70, 1998 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-9771447

RESUMO

The first identification of haemoglobin Le Lamentin (alpha 20 (B1) His-->Gln) in a British patient is described. The patient was a 69 year old asymptomatic white male being screened for diabetes, whose blood was undergoing its first ever analysis for glycated haemoglobin using a Glycomat II analyser. Identification of the haemoglobin variant was by electrospray mass spectrometry.


Assuntos
Hemoglobinas Anormais/análise , Idoso , Diabetes Mellitus/sangue , Hemoglobinometria/métodos , Humanos , Masculino , Espectrometria de Massas/métodos , Reino Unido
12.
J Nurs Care Qual ; 12(2): 27-32, 1997 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-9397637

RESUMO

Continuous Quality improvement (CQI) has undergone radical change as health care facilities merge, expand, and modify their existing services. CQI has shifted from a centralized position in health care organizations, to unit based, to product lines. This paper describes one product line's endeavors to develop a Quality Plan to direct CQI activities. One particular strength of our innovation is that the Quality Plan was developed with attention to the important balance of interdisciplinary cooperation and maintenance of appropriate discipline boundaries.


Assuntos
Serviços de Saúde Mental/normas , Administração de Linha de Produção/normas , Gestão da Qualidade Total/organização & administração , Hospitais de Veteranos/normas , Humanos , Relações Interprofissionais , Participação nas Decisões , Massachusetts , Inovação Organizacional
16.
18.
Urol Res ; 16(5): 381-4, 1988.
Artigo em Inglês | MEDLINE | ID: mdl-3059656

RESUMO

A Collagen/Vicryl (Polyglactin) composite membrane (developed for use in urinary tract surgery) has been incubated in cultures of radioactively labelled urinary tract pathogens vis Escherichia coli, Staphylococcus epidermidis, and Proteus mirabilis for up to 1 h. For comparison, collagen film, Vicryl mesh, and a number of absorbable and non-absorbable sutures were similarly tested. Following incubation, samples were also examined by scanning electron microscopy. Under the experimental conditions employed, only minimal adherence of the micro-organisms to the collagen coated Vicryl mesh, its two individual components, as well as Vicryl and nylon sutures was observed. Significantly greater numbers of bacteria, however, adhered to silk and Chromic Catgut. The results suggest that adherence of microorganisms to the prosthesis even in infected urine is unlikely to develop into a microcolony of bacteria. However, it should be emphasised that great care must be exercised when extrapolating from the in-vitro to the in-vivo situation.


Assuntos
Aderência Bacteriana , Materiais Biocompatíveis , Poliglactina 910 , Polímeros , Sistema Urinário/cirurgia , Escherichia coli , Humanos , Técnicas In Vitro , Teste de Materiais , Proteus mirabilis , Staphylococcus epidermidis , Suturas
19.
J Am Vet Med Assoc ; 188(12): 1426-31, 1986 Jun 15.
Artigo em Inglês | MEDLINE | ID: mdl-3528096

RESUMO

Posthypoglycemic hyperglycemia (rebound hyperglycemia) after overdosing of insulin was diagnosed in 6 cats with diabetes mellitus. Administration of excessive insulin induced hypoglycemia within 4 to 8 hours, followed by rebound hyperglycemia. Diagnosis was made by serial blood glucose determinations during a 20- to 24-hour period after insulin administration. Four cats had a history of difficulty in regulating the diabetic state. In 2 cats, rebound hyperglycemia was diagnosed on routine serial blood glucose determinations. All of the cats were hyperglycemic for most of the day. Rebound hyperglycemia was observed with both intermediate (neutral protamine hagedorn) and long-acting (protamine zinc iletin) insulins, and the range of insulin doses at which the disorder developed overlapped previously determined therapeutic doses for these insulins in the cat. Urine glucose and single afternoon blood glucose determinations were inadequate and potentially misleading in monitoring diabetic cats receiving excessive amounts of insulin.


Assuntos
Doenças do Gato/tratamento farmacológico , Diabetes Mellitus/veterinária , Hiperglicemia/veterinária , Insulina/efeitos adversos , Animais , Gatos , Diabetes Mellitus/tratamento farmacológico , Feminino , Hiperglicemia/induzido quimicamente , Insulina/uso terapêutico , Masculino
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...