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1.
Endocrinology ; 140(2): 556-61, 1999 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-9927277

RESUMO

The steroid hormone estradiol (E2) elicits a spectrum of systemic and uterotropic responses in vivo. For example, E2 treatment of ovariectomized adult and sexually immature rodents leads to uterine leukocytic infiltration, cell proliferation, and organ growth. E2-regulated growth is also associated with a variety of normal and pathological phenotypes. Historically, the uterine growth response has been used as the key model to understand the molecular and biochemical mechanisms underlying E2-dependent growth. In this study, genome exclusion mapping identified two quantitative trait loci (QTL) in the mouse, Est2 and Est3 on chromosomes 5 and 11, respectively, that control the phenotypic variation in uterine wet weight. Both QTL are linked to a variety of E2-regulated genes, suggesting that they may represent loci within conserved gene complexes that play fundamental roles in mediating the effects of E2. Interaction and multiple trait analyses using the uterine leukocyte response and wet weight suggest that Est4, a QTL on chromosome 10, may encode an interacting factor that influences the quantitative variation in both responses. Our results show that E2-dependent responses can be genetically controlled and that a genetic basis may underlie the variation observed in many E2-dependent phenotypes.


Assuntos
Mapeamento Cromossômico , Estradiol/fisiologia , Variação Genética/genética , Característica Quantitativa Herdável , Animais , Cromossomos Humanos Par 10/genética , Cromossomos Humanos Par 11/genética , Cromossomos Humanos Par 5/genética , Feminino , Humanos , Leucócitos/fisiologia , Camundongos , Camundongos Endogâmicos C3H , Camundongos Endogâmicos C57BL , Tamanho do Órgão/fisiologia , Fenótipo , Útero/anatomia & histologia , Útero/citologia , Útero/fisiologia
2.
Epilepsia ; 39(4): 438-41, 1998 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-9578035

RESUMO

A patient with recurrent episodes of complex partial status epilepticus and a distinctive pattern of periodic lateralized epileptiform discharges (PLEDs) is presented. The patient was subsequently shown to have a mitochondrial disorder of the MELAS type, a hitherto unreported association. The case illustrates that CPSE should be added to the list of possible causes of acute neurological deterioration in MELAS patients.


Assuntos
Eletroencefalografia/estatística & dados numéricos , Epilepsia Parcial Complexa/diagnóstico , Síndrome MELAS/diagnóstico , Estado Epiléptico/diagnóstico , Diagnóstico Diferencial , Humanos , Masculino , Pessoa de Meia-Idade
3.
J Neurol Neurosurg Psychiatry ; 51(2): 218-22, 1988 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-3346686

RESUMO

Three patients with dominant anterior cerebral artery territory infarction demonstrated a severe disturbance of upper limb motor control with impaired bimanual coordination, the "alien hand" sign, and intermanual conflict, in addition to signs of callosal interruption and a transcortical motor aphasia. Recordings of movement-related potentials in one patient showed an attenuated Bereitschaftspotential and a greater asymmetry of the NS' component of the premotor negativity with left finger than with right finger movement. The impairment of bimanual motor control and associated abnormal motor behaviour of the right hand in these cases are postulated to be due to involvement of the supplementary motor area and related areas of the medial frontal cortex.


Assuntos
Infarto Cerebral/fisiopatologia , Dominância Cerebral/fisiologia , Lateralidade Funcional/fisiologia , Desempenho Psicomotor/fisiologia , Idoso , Apraxias/fisiopatologia , Eletroencefalografia , Potenciais Evocados , Feminino , Lobo Frontal/fisiopatologia , Hemiplegia/fisiopatologia , Humanos , Pessoa de Meia-Idade , Córtex Motor/fisiopatologia , Tomografia Computadorizada por Raios X
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