Localized Cutaneous Argyria at the Site of a Prior Melanoma Excision Confirmed by Scanning Electron Microscopy With Energy Dispersive X-ray Analysis.

ABSTRACT: Localized cutaneous argyria is a rare condition caused by the accumulation of silver particles in the skin, leading to blue-gray discoloration. Argyria may mimic melanoma and lead to misdiagnosis. We present a patient with a history of melanoma that developed a blue-gray nodule at a prior melanoma graft. The diagnosis was confirmed using scanning electron microscopy and energy dispersive x-ray analysis. These techniques differentiate argyria from melanoma and can be performed on formalin-fixed, paraffin-embedded, tissue sections. Health care providers should be alert that argyria may mimic recurrent melanoma in patients unaware of silver exposure.

Vector competence of Aedes albopictus from Virginia and Georgia for chikungunya virus isolated in the Comoros Islands, 2005.

We evaluated recently colonized samples from Virginia and Georgia (USA) of Aedes albopictus, an important vector of chikungunya virus (CHIKV), to determine whether they became infected with and transmitted COM125, a CHIKV isolate from the Comoros Islands. Seven days after imbibing an infective blood meal containing a minimum of 8.5×10(4) plaque-forming units (pfu)/mL, 31-86% of A. albopictus from the counties of Fairfax, Loudon, Rockingham, and Suffolk, Virginia, and Fulton, Georgia were infected. The average viral titer per mosquito was 1.1×10(4) pfu/mL (2×10(2)-3.3×10(4)). We detected CHIKV in salivary expectorate of infected mosquitoes from Rockingham (8%), Fulton (22%), and Loudon (48%) counties 7 days after blood feeding. Because CHIKV has no vaccines or specific antiviral treatments, vector control and education are critical to prevent its transmission. We discuss how local populations of A. albopictus could transmit CHIKV introduced to the southeastern USA from the Indian Ocean or Indian Subcontinent.