A protocol for induction of tolerance to apomorphine in patients with parkinson disease and hypersensitivity to apomorphine

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Monoclonal antibody desensitization in a patient with a generalized urticarial reaction following denosumab administration.

Denosumab is a human monoclonal antibody indicated for the treatment of osteoporosis in postmenopausal women with a high risk of fractures. To our knowledge, no cases of desensitization to this drug have been described in the literature. We report the first case of generalized urticarial reaction and facial angioedema after therapy with denosumab. A subcutaneous desensitization protocol was successfully completed in this patient. Rapid desensitization is a promising method for the delivery of denosumab after a hypersensitivity reaction, and should be considered in osteoporosis treatment when no acceptable therapeutic alternatives are available.

Gammapatía monoclonal IgG Kappa asociada al síndrome de Sjögren. A propósito de un caso / Monoclonal gammapathy IgG Kappa in patients with Sjögren syndrome. One case review

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