Morphometrical and morphological analysis of lateral ventricles in schizophrenia patients versus healthy controls.

The goal of this report was to highlight lateral ventricle morphology and volume differences between schizophrenia patients and matched controls. Subjects identified as suitable for analysis comprised 15 schizophrenia patients and 15 healthy subjects. The method applied is three-dimensional (3D) volume rendering starting from structural magnetic resonance imaging (MRI) studies of selected ventricular regions. Differences between groups relative to the global ventricular system and its subdivisions were found. Total lateral ventricle volume, right ventricle volume and left ventricle volume were all higher in schizophrenia patients than in controls; unilateral differences between the two groups were also outlined (right ventricle volume>left ventricle volume in schizophrenia patients vs. healthy subjects). Furthermore, occipital and frontal horn enlargement was found in schizophrenia patients compared with normal controls, but the difference in the temporal horn was not statistically significant. A substantial difference was noted in lateral ventricle morphology between the two groups. Our findings were consistent with the literature and may shed light on some of the discrepancies in previous reports on differences in lateral ventricle volume enlargement.

Gender role identity in a sample of Italian male homosexuals.

Gender role is a multifactorial concept, as gender-related attitudes, behaviors, and personality are partially autonomous. The aim of the study was to evaluate the prevalent gender role identity in a sample of male homosexuals. One hundred male homosexuals and 50 male heterosexuals matched for age and sex, have been assessed with the Italian version of the Bem Sex-Role Inventory (BSRI; Bem, 1974). Statistically significant differences have been found between the two groups at the dimensions "Masculine" (z = 1.963; p = 0.001) and "Androgyny" (z = 2.367; p < 0.0001). The results obtained from the present study tend to confirm that homosexuals view themselves as adrogynous individuals, sharing both features of masculine and feminine gender roles.

Defense mechanisms in a sample of non-psychiatric obese subjects.

The aim was to assess the prevalent defense mechanisms in a sample of obese subjects; since specific defensive styles may interfere with the management of stressors and emotions, they may also influence the onset, the severity, and the maintenance of obesity. 70 obese subjects and 70 healthy normal-weight volunteers were assessed using the Defense Mechanisms Inventory -- DMI. Significant differences between groups have emerged at Turning Against Object (t=-5.30; p<0.0001), Projection (t=-5.55; p<0.0001), Turning Against Self (t=-4.87; p<0.0001) and Reversal (t=-3.61; p<0.0001) variables. Within the obese group, significant differences have been found at Turning Against Object (U=264; p=.001) and Projection (U=359; p=.042) scales, both higher in males. No significant differences on DMI scores in relation to the severity of obesity have been observed. An inadequate defensive structure might represent a vulnerability to emotional states and stressful life events. The assessment of defense mechanisms may provide a valid tool for long-term treatments of obesity.

Urinary incontinence in schizophrenic patients treated with atypical antipsychotics: urodynamic findings and therapeutic perspectives.

Objective The present study was a urodynamic evaluation of schizophrenic patients with urinary incontinence occurring during treatment with atypical antipsychotics Methods A total of 12 schizophrenic patients (mean age = 30.7 years, SD = 6.5) presenting urinary incontinence during treatment with atypical antipsychotics at stable doses underwent urodynamic evaluations. Clinical assessment included the administration of Positive and Negative Syndrome Scale (PANSS) Results Four patients out of 12 presented urodynamic patterns consistent with an overactive bladder, while five patients presented reduced bladder compliance; only three patients showed normal urodynamic patterns Conclusion Detrusor overactivity is a condition associated with urinary incontinence in schizophrenic patients treated with atypical antipsychotics. Urodynamic evaluations can improve our knowledge of the mechanisms that subtend atypical antipsychotic-induced incontinence, an invalidating side-effect with strong repercussion on compliance and rehabilitation in schizophrenic patients.

The effect of mirtazapine augmentation of clozapine in the treatment of negative symptoms of schizophrenia: a double-blind, placebo-controlled study.

The development of therapeutic strategies to effectively treat negative symptoms remains one of the primary goals in the treatment of schizophrenia. Mirtazapine is the first of a new class of dual action compounds, the noradrenergic and specific serotonergic antidepressants (NaSSa), whose activity is related to the enhancement of noradrenergic and serotonergic transmission by a presynaptic alpha2 antagonism and postsynaptic 5-HT2 and 5-HT3 antagonism, respectively. This study was a 8-week double-blind, randomized, placebo-controlled trial of 30 mg adjunctive mirtazapine to clozapine therapy in 24 patients with DSM-IV schizophrenia. The main finding at the end of the trial was a significant reduction on the Scale for the Assessment of Negative Symptoms (SANS) total scores in the mirtazapine group compared to placebo (P<0.01) with a significant improvement on the SANS subscales avolition/apathy and anhedonia/asociality. The Brief Psychiatric Rating Scale total score at week 8 showed superiority of mirtazapine over placebo. These findings suggest a potential role for mirtazapine as an augmentation strategy in the treatment of negative symptoms of schizophrenia.