[Change in the content of a series of components of rat lung connective tissue in the process of aging]. / Izmenenie soderzhaniia riada komponentov soedinitel'noi tkani legkikh krys v protsesse stareniia.

Content of soluble and insoluble collagen, glycosamine glycans, glycoproteins, lipids and nucleic acids was studied in rat lungs during postnatal ontogenesis (up to 32 months). Three age groups of animals, corresponding to juvenile, mature and old age, were used. Intensive collagenoformation and high content of soluble collagen fraction were found in animals of juvenile age. Mature age was characterized by static equilibrium between soluble and insoluble collagen fractions as well as by stabilization in concentration of RNA, hexuronic acids, hexoses, tyrosine, sialic acids and total lipids. Decrease of DNA concentration with simultaneous increase in phospholipid content preceded in ageing the alteration in collagen composition - elevation in insoluble and loss of soluble its fractions. At the ageing period content of glycosamines was relatively decreased but concentration of other substances varied slightly.

[Content of hexuronic acids, hexoses and tyrosine in the lung tissue in experimental pneumoconiosis]. / Soderzhanie geksuronovykh kislot, geksoz i tirozina v legochnoi tkani pri eksperimental'nykh pnevmokoniozakh

Content of hydroxyproline, thyrosine, hexuronic acids, hexoses and dry weight of lungs were studied in animals with pneumoconiosis, caused by various agents: two types of silicosis, induced by crystalline and condensed modifications of silica, and anthracosis, caused by anthracite. The data obtained showed that in all the types of pneumoconiosis dry weight of defatted lungs was increased with simultaneous increase of hydroxyproline content in the tissue. The more pronounced alterations were observed in silicosis. In all the types of pneumoconiosis within the experimental period content of hexuronic acids was higher in impaired animals as compared with control ones; the increase in content of hexuronic acids preceded the accumulation of hydroxyproline. Content of hexoses and thyrosine was distinctly increased within 2 days, which apparently correlated with the processes of exudation. Then it was decreased and at the later steps of the impairment amount of hexoses and thyrosine was shown to increase with simultaneous accumulation of hydroxyproline. Dynamics of accumulation of non-collagen components of connective tissue in lungs depended upon the type of a dust to which the animals were exposed.