RESUMO
The adsorbing activity of granulated carbonic sorbents SKN and KAU, as well as their oxidated forms, containing protogenic carboxylic and phenolic groups with respect to Shigella flexneri, Salmonella typhimurium, Escherichia coli, Streptococcus aureus and Pseudomonas aeruginosa pathogenic strains has been studied. As shown in this study, the process of interaction between microorganisms and carbonic sorbents has two stages. At the first stage the main role is played by long-distance electrostatic forces and at the second stage, by Van der Waals short-distance forces, as well as bonds formed between cell structures and surface groupings of carbonaceous materials. In the mechanism of interaction between microbial cells and carbons the geometry of carbon surface plays an important role. KAU(0)-1 exhibits the highest degree of adhesion with respect to pathogenic bacteria.
Assuntos
Aderência Bacteriana , Desintoxicação por Sorção , Adsorção , Carvão Vegetal , Escherichia coli/patogenicidade , Porosidade , Pseudomonas aeruginosa/patogenicidade , Salmonella typhimurium/patogenicidade , Shigella flexneri/patogenicidade , Staphylococcus aureus/patogenicidade , Propriedades de SuperfícieAssuntos
Carvão Vegetal/administração & dosagem , Cobre/administração & dosagem , Modelos Animais de Doenças , Quercetina/administração & dosagem , Infecções Estafilocócicas/tratamento farmacológico , Infecção dos Ferimentos/tratamento farmacológico , Zinco/administração & dosagem , Animais , Avaliação Pré-Clínica de Medicamentos , Curativos Oclusivos , Ratos , Infecções Estafilocócicas/fisiopatologia , Cicatrização/efeitos dos fármacos , Cicatrização/fisiologia , Infecção dos Ferimentos/fisiopatologiaRESUMO
To give sorbents the bactericidal action, a modification of the carbonic sorbents by the metals is suggested. Modification of the SKN and KAU sorbents by copper and zinc didn't reduce sorption by them of microorganisms and their toxins. Inhibitory effect of a sorbent was provided by the lower concentrations of the copper and zinc than by those which in the solution of metallic salts had only bacteriostatic effect.
Assuntos
Bactérias/isolamento & purificação , Carbono , Zinco , Adsorção , Toxinas Bacterianas/isolamento & purificação , CobreAssuntos
Cuidados Críticos , Hemoperfusão , Síndrome de Stevens-Johnson/terapia , Pré-Escolar , Humanos , MasculinoRESUMO
The use of SKN P-1 and SKN P-2 carbonic enterosorbents in the complex treatment of the patients contributed to decrease in pronouncement of cholemic intoxication. A method is easy, noninvasive, its use is recommended in patients, the elderly and senile in particular, with obstructive jaundice.
Assuntos
Carbono/uso terapêutico , Colestase/terapia , Adsorção , Colestase/metabolismo , Terapia Combinada , Estudos de Avaliação como Assunto , Humanos , Neoplasias/metabolismo , Neoplasias/terapia , Cuidados Pré-Operatórios , Fatores de TempoRESUMO
In the experiments on rats with modelled bile duct obstruction and hepatic failure, the pronounced detoxicative value of the SKN P-1 and SKN P-2 carbonic sorbents is proved.
Assuntos
Carvão Vegetal/uso terapêutico , Colestase Extra-Hepática/terapia , Doenças do Ducto Colédoco/terapia , Hemoperfusão/métodos , Toxemia/terapia , Animais , Colestase Extra-Hepática/sangue , Doenças do Ducto Colédoco/sangue , Feminino , Masculino , RatosAssuntos
Carvão Vegetal/uso terapêutico , Colestase/terapia , Hemoperfusão , Adsorção , Aderência Bacteriana/efeitos dos fármacos , Toxinas Bacterianas/antagonistas & inibidores , Carvão Vegetal/farmacologia , Colestase/microbiologia , Avaliação Pré-Clínica de Medicamentos , Enterobacteriaceae/efeitos dos fármacos , Enterotoxinas/antagonistas & inibidores , Humanos , Técnicas In VitroAssuntos
Hemoperfusão , Pancreatite/terapia , Peritonite/terapia , Ressuscitação , Adulto , Idoso , Animais , Cães , Humanos , Pessoa de Meia-IdadeRESUMO
The results of study of the sorption properties of phenolformaldehide-activated coal in respect of several physiologically active substances from the physiological saline under static conditoins and under conditions of autohemoperfusion of the limb vessels in experimental animals are presented. Phenolformaldehide-activated coal proved to sorb actively serotonin, adrenaline and noradrenaline, and--to a lesser extent--histamine from physiological saline. Serotonin, adrenaline, noradrenaline, and acetylcholine are sorbed well, histamine--less, papaverine--very weakly from the flowing blood. No alteration of the systemic arterial blood pressure was noted with the inclusion of phenolformaldehide-activated coal into the animal's arterial circulation; a fall of perfusion pressure associated with the decreased vascular resistance occured in a number of cases.